{"id":"W4283033359","doi":"10.15252/embr.202154532","title":"Metabolic routing maintains the unique fatty acid composition of phosphoinositides","year":2022,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Institut Périmètre de physique théorique; Université de Strasbourg","keywords":"Phosphatidic acid; Diacylglycerol kinase; Phosphatidylinositol; Biochemistry; Arachidonic acid; Fatty acid; Chemistry; Phosphatidate; Phospholipase; Lipid metabolism; Biology; Signal transduction; Phospholipid; Enzyme; Protein kinase C","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414853,0.0004179497,0.0002955809,0.0002392718,0.0001962962,0.000555418,0.0002219529,0.0002971466,0.0008558623],"category_scores_gemma":[0.0001882987,0.0002473378,0.0001768213,0.000188369,0.0002893644,0.0004308431,0.0004659067,0.0004223742,0.0005263351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004887611,"about_ca_system_score_gemma":0.0002964518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005608353,"about_ca_topic_score_gemma":0.0006014389,"domain_scores_codex":[0.999833,0.00002397787,0.00001094741,0.00005936527,0.00003718386,0.00003554629],"domain_scores_gemma":[0.999841,0.00002029448,0.00004704097,0.00003073381,0.00002640383,0.0000344776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007119079,0.000003352771,0.0001517312,0.000009528993,0.000001162113,0.0000209888,0.000004734247,0.00003256451,0.999166,0.00008186106,0.000008826252,0.0004480058],"study_design_scores_gemma":[0.000008561459,0.00006183238,0.005314578,0.000004089516,0.000007967959,0.0001947251,0.00002765917,0.001113036,0.9911944,0.0001421905,0.001924609,0.0000065012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940503,0.001078215,0.002825804,0.0001006636,0.00001968767,0.00001485912,0.0003100696,0.00008574021,0.001514668],"genre_scores_gemma":[0.9948848,0.000396377,0.001772068,0.00002679024,0.000007622158,0.00001950182,0.0004746456,0.00003737349,0.002380764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008558623,"threshold_uncertainty_score":0.003546178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00746274448248985,"score_gpt":0.2236887163970616,"score_spread":0.2162259719145718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}