{"id":"W4283034542","doi":"10.21203/rs.3.rs-1582705/v1","title":"Assessing use of surrogate outcome measures in randomized controlled trials investigating venous thromboembolism prophylaxis","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Venous Thromboembolism Diagnosis and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; McMaster University","funders":"","keywords":"Medicine; Surrogate endpoint; Randomized controlled trial; Venous thromboembolism; Internal medicine; Clinical trial; MEDLINE; Thrombosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.6936184,0.003268915,0.01981882,0.02223847,0.001919776,0.01194914,0.006282146,0.008120598,0.007111624],"category_scores_gemma":[0.8747106,0.002559616,0.03139952,0.02480442,0.007958139,0.0122381,0.006477057,0.005797393,0.0008867224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007732688,"about_ca_system_score_gemma":0.009565979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000861778,"about_ca_topic_score_gemma":0.0009891853,"domain_scores_codex":[0.08377891,0.6712204,0.1905055,0.01098919,0.04250093,0.001004985],"domain_scores_gemma":[0.0321516,0.866305,0.07710499,0.01180873,0.01192081,0.0007089399],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"systematic_review","study_design_gemma":"observational","study_design_scores_codex":[0.01908936,0.0002917116,0.05532426,0.6057872,0.2151983,0.0003896325,0.001982654,0.003075458,0.0005511509,0.009147758,0.002884591,0.08627801],"study_design_scores_gemma":[0.03455463,0.01658633,0.09387914,0.3951776,0.3420428,0.001909674,0.00189276,0.01732329,0.003413671,0.05887106,0.03340734,0.0009416273],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05037984,0.7672189,0.1117718,0.009556245,0.005307585,0.04020962,0.006483477,0.0005713474,0.008501199],"genre_scores_gemma":[0.6726135,0.06948714,0.1253804,0.005407359,0.001936993,0.1206539,0.003548748,0.0002284578,0.0007434211],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.3063816,"threshold_uncertainty_score":0.3778231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3732276490719535,"score_gpt":0.4962809473423301,"score_spread":0.1230532982703766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}