{"id":"W4283068621","doi":"10.3390/polym14122447","title":"Hepatotropic Peptides Grafted onto Maleimide-Decorated Nanoparticles: Preparation, Characterization and In Vitro Uptake by Human HepaRG Hepatoma Cells","year":2022,"lang":"en","type":"article","venue":"Polymers","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Circulatory and Respiratory Health; Cancéropôle Grand Ouest; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Labex Iron","keywords":"Maleimide; In vitro; Characterization (materials science); Peptide; Chemistry; Nanoparticle; Polymer chemistry; Materials science; Biochemistry; Nanotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009052976,0.0001542396,0.0001447437,0.00006781276,0.0001708966,0.00003781074,0.0001298898,0.00006065248,0.00008175397],"category_scores_gemma":[0.000007311805,0.0001748561,0.00004088172,0.0001438738,0.00004332317,0.00001455318,0.0001056894,0.00007364103,0.000006256708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000329595,"about_ca_system_score_gemma":0.00004141079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002748106,"about_ca_topic_score_gemma":0.0001553358,"domain_scores_codex":[0.9988729,0.0001075131,0.0002785054,0.00037251,0.0001220536,0.0002464679],"domain_scores_gemma":[0.999584,0.000003722838,0.0001018072,0.000205711,0.00003207709,0.00007271222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002844083,0.00007865581,0.01226118,0.000006681303,0.00002369852,0.000004179034,0.0001791137,0.00001436137,0.9856957,0.000002715943,0.0006511261,0.0007981595],"study_design_scores_gemma":[0.0004760916,0.0003042714,0.008379382,0.000004231399,0.00001173158,0.000007154192,0.0002303697,0.000408257,0.986641,0.000006505639,0.003331007,0.0001999384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988339,0.0005333528,0.00003943444,0.0001035389,0.0001037616,0.0001977836,0.0001196472,0.00001998671,0.00004860723],"genre_scores_gemma":[0.9970126,0.0001173663,0.00002066919,0.0003765788,0.0000352686,0.0001000477,0.00112383,0.00002101865,0.001192609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003881797,"threshold_uncertainty_score":0.7130427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007381450501664744,"score_gpt":0.2295442924558591,"score_spread":0.2221628419541943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}