{"id":"W4283070056","doi":"10.3390/cancers14122985","title":"Low-Dose Metronomic Topotecan and Pazopanib (TOPAZ) in Children with Relapsed or Refractory Solid Tumors: A C17 Canadian Phase I Clinical Trial","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Children's Hospital of Eastern Ontario; London Health Sciences Centre; Centre Hospitalier Universitaire Sainte-Justine; C17 Council; University of Toronto; BC Children's Hospital; SickKids Foundation; Hospital for Sick Children","funders":"Garron Family Cancer Centre; Hospital for Sick Children","keywords":"Pazopanib; Medicine; Topotecan; Neutropenia; Pharmacokinetics; Adverse effect; Internal medicine; Pharmacology; Cmax; Oncology; Refractory (planetary science); Maximum tolerated dose; Tolerability; Chemotherapy; Gastroenterology; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003151906,0.0001628145,0.0004122722,0.0002904428,0.0001505672,0.00001938618,0.0001165301,0.00004253564,0.000427687],"category_scores_gemma":[0.0001353682,0.000131211,0.00006063817,0.0002767863,0.0001453474,0.00006817912,0.00005138719,0.0005900594,0.00000808093],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002958779,"about_ca_system_score_gemma":0.00628906,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.04016335,"about_ca_topic_score_gemma":0.06658041,"domain_scores_codex":[0.9983171,0.0001746225,0.0003249948,0.0004481153,0.0002466946,0.0004885098],"domain_scores_gemma":[0.9987898,0.00007886319,0.00008664792,0.0003048312,0.0000203522,0.0007194529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.66707,0.002969279,0.1523436,0.00009584292,0.00170765,0.01122496,0.00106726,0.0002740419,0.0008994593,0.00003935058,0.009604667,0.1527039],"study_design_scores_gemma":[0.7305311,0.0800493,0.1731766,0.0002239085,0.0003475411,0.0007769195,0.001241685,0.0006772847,0.0009326825,0.00002697221,0.01124198,0.0007740472],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976557,0.0001113739,6.378892e-7,0.0003083295,0.0001397788,0.001310838,0.0001111914,0.00002331231,0.0003387725],"genre_scores_gemma":[0.998342,0.00006806719,0.00003902559,0.0004856705,0.0001852988,0.000246703,0.00006074296,0.00003508457,0.0005373544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1519298,"threshold_uncertainty_score":0.9993443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03863658546690084,"score_gpt":0.3691654049272565,"score_spread":0.3305288194603556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}