{"id":"W4283070994","doi":"10.1101/2022.06.16.496505","title":"Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"DOD Prostate Cancer Research Program; Congressionally Directed Medical Research Programs; National Center for Advancing Translational Sciences; National Institutes of Health; Georgia Clinical and Translational Science Alliance; Boler Family Foundation; Indiana Clinical and Translational Sciences Institute; University of Notre Dame; Elsa U. Pardee Foundation; U.S. Department of Defense","keywords":"Cancer research; Prostate cancer; Tumor microenvironment; Immunotherapy; Cancer; Immune checkpoint; Immune system; Cancer immunotherapy; Biology; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001443744,0.0002497163,0.0001771111,0.0002019012,0.00008497522,0.0002714883,0.0001358672,0.0002402284,0.002102122],"category_scores_gemma":[0.00007829844,0.0001062513,0.0001379471,0.0001054374,0.0002082314,0.0001686346,0.0002655883,0.0005590852,0.0004447834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001977519,"about_ca_system_score_gemma":0.0001330377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001576189,"about_ca_topic_score_gemma":0.0002633407,"domain_scores_codex":[0.9999338,0.000008166051,0.000002558043,0.00001506213,0.00002524417,0.00001521227],"domain_scores_gemma":[0.9999661,0.000005723817,0.000008558722,0.000004611236,0.000003142261,0.00001189551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000750786,0.00001699965,0.0001258896,0.00002643101,0.000003310696,0.00002185431,0.000003489351,0.000259779,0.9974332,0.0002104574,0.00009988181,0.001723591],"study_design_scores_gemma":[0.00002335304,0.0001380673,0.00101426,0.000003200822,0.000006301965,0.0001191626,0.00000413326,0.001659425,0.9928374,0.0001258027,0.00406632,0.000002718178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665079,0.005964353,0.01981336,0.0005451696,0.0001297114,0.00008192794,0.0008020103,0.00069757,0.005457921],"genre_scores_gemma":[0.9867334,0.001118116,0.005836135,0.0001129299,0.00002389687,0.00003178503,0.0004872449,0.00006867728,0.005587844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002102122,"threshold_uncertainty_score":0.007032335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005945880075315161,"score_gpt":0.244568812795847,"score_spread":0.2386229327205318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}