{"id":"W4283071318","doi":"10.3390/molecules27123869","title":"TNKPVI, a Putative Bioaccessible Pharmacophore of Anti-Inflammatory Potato Patatin-Derived Decapeptide DIKTNKPVIF","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; State University of New York Fredonia; University of Ottawa","keywords":"Chemistry; Peptide; Trypsin; Chymotrypsin; Biochemistry; Proteases; Pharmacophore; Cathepsin G; Pepsin; Lipopolysaccharide; Hydrolysate; Pharmacology; Enzyme; Hydrolysis; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002493399,0.0002643053,0.0002992543,0.0001189499,0.0002384444,0.00002542354,0.0004381341,0.00006668977,0.0001636515],"category_scores_gemma":[0.00005614282,0.0002558367,0.0002193083,0.0002496889,0.0002014801,0.000009268784,0.00054455,0.0001649124,0.000007606452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002900679,"about_ca_system_score_gemma":0.0001301549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000698732,"about_ca_topic_score_gemma":0.00001005979,"domain_scores_codex":[0.9981696,0.0002415599,0.0003891314,0.0005220111,0.0003378369,0.0003398862],"domain_scores_gemma":[0.999091,0.00002277366,0.00030828,0.0003541287,0.0001241917,0.00009960881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001661251,0.0001615171,0.003796521,0.00003453455,0.0001876961,0.00003092018,0.0001844495,0.000812057,0.9913171,0.00004264843,0.000506438,0.002760017],"study_design_scores_gemma":[0.0007308366,0.0003323184,0.004519099,0.00001114863,0.00004495373,0.00001588446,0.0005441037,0.0002078421,0.9880863,0.0001404144,0.005053126,0.0003140067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954685,0.001856347,0.0009100163,0.00008819966,0.00009211479,0.0003413841,0.0002547296,0.00002457637,0.0009641155],"genre_scores_gemma":[0.9974883,0.0001443168,0.001216664,0.0003097662,0.00007789908,0.000202625,0.0002960316,0.00004373107,0.0002207328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004546688,"threshold_uncertainty_score":0.9999894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009009329571438643,"score_gpt":0.2525146405166188,"score_spread":0.2435053109451802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}