{"id":"W4283073514","doi":"10.1182/blood.2021014901","title":"Enasidenib vs conventional care in older patients with late-stage mutant-<i>IDH2</i> relapsed/refractory AML: a randomized phase 3 trial","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Medical Research Council; National Institute for Health and Care Research; Celgene; Bristol-Myers Squibb","keywords":"Medicine; Hazard ratio; Internal medicine; Gastroenterology; Randomized controlled trial; Clinical endpoint; Cytarabine; Refractory (planetary science); Surgery; Confidence interval; Myeloid leukemia; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000997829,0.0007387369,0.001237244,0.0001695468,0.0002214553,0.0005341038,0.0004197499,0.0006433259,0.003510399],"category_scores_gemma":[0.0007699424,0.0002155575,0.0009991613,0.000219081,0.0004747115,0.0005009276,0.0002370499,0.001815243,0.0003411316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005187995,"about_ca_system_score_gemma":0.0006648229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007248282,"about_ca_topic_score_gemma":0.002462254,"domain_scores_codex":[0.9998131,0.00009842202,0.00001266026,0.00003156708,0.00001313565,0.00003118108],"domain_scores_gemma":[0.9995618,0.0001023407,0.0001073619,0.00002181201,0.00002357147,0.000183004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9557815,0.005945633,0.001694884,0.0004459293,0.0007685072,0.00006869963,0.00006599562,0.0005304,0.00447976,0.0001965292,0.001196727,0.02882547],"study_design_scores_gemma":[0.8923588,0.09972417,0.00458406,0.00003864265,0.0004831624,0.00008255983,0.00003278317,0.0006689563,0.0004858522,0.0002313794,0.001296772,0.00001291207],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927863,0.003180808,0.0002514461,0.0004175029,0.0002323053,0.001143067,0.0003949618,0.00004603203,0.00154741],"genre_scores_gemma":[0.9929827,0.001909204,0.0007272157,0.0009228015,0.0002393304,0.001133628,0.0006913752,0.000008596863,0.001385041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003510399,"threshold_uncertainty_score":0.01174343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125520532681904,"score_gpt":0.2783481008911824,"score_spread":0.2670928955643633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}