{"id":"W4283078101","doi":"10.1182/blood.2021014875","title":"A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institutes of Health; Wellcome Trust","keywords":"Biology; Rhesus macaque; Myeloid; Haematopoiesis; Progenitor cell; Transplantation; Cancer research; Immunology; CRISPR; Gene; Genetics; Stem cell; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003757096,0.0001072084,0.0002762392,0.0001287986,0.0002138834,0.000008943841,0.00009456741,0.00004625547,0.00006923246],"category_scores_gemma":[0.0005542493,0.0001011593,0.0001355017,0.0002524918,0.0001091422,0.00004988756,0.0002205753,0.0001975738,4.899632e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004171528,"about_ca_system_score_gemma":0.0002968759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006453606,"about_ca_topic_score_gemma":0.000009035049,"domain_scores_codex":[0.9988817,0.00005536024,0.0003382516,0.0002525602,0.0002511429,0.0002209929],"domain_scores_gemma":[0.9991128,0.0003268704,0.00009336316,0.0002068911,0.0001644467,0.00009563865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002201623,0.00674198,0.2921204,0.009336204,0.001186606,0.0001957188,0.002270364,0.0004544314,0.6526667,0.00329018,0.003312635,0.02622313],"study_design_scores_gemma":[0.02508915,0.003669156,0.04170597,0.001156255,0.001915152,0.001979596,0.006306523,0.674028,0.2314628,0.01164324,0.0003148458,0.0007293745],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949631,0.0004514245,0.002735648,0.000474112,0.00001634325,0.0006380567,0.0002012363,0.00005050591,0.0004695613],"genre_scores_gemma":[0.9695845,0.0000103285,0.02981637,0.00003696932,0.00002402133,0.0002257527,0.0000540827,0.00001928365,0.000228663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6735736,"threshold_uncertainty_score":0.4125156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08343526588746084,"score_gpt":0.3426128571762473,"score_spread":0.2591775912887865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}