{"id":"W4283078101","doi":"10.1182/blood.2021014875","title":"A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institutes of Health; Wellcome Trust","keywords":"Biology; Rhesus macaque; Myeloid; Haematopoiesis; Progenitor cell; Transplantation; Cancer research; Immunology; CRISPR; Gene; Genetics; Stem cell; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000285328,0.0003636679,0.0002383321,0.0004607914,0.0003211162,0.0003306151,0.0002376403,0.0004962831,0.002242714],"category_scores_gemma":[0.0002475308,0.0001418722,0.0002511063,0.0001378193,0.0002914251,0.0002111001,0.0003369057,0.0009032476,0.0003991121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002940609,"about_ca_system_score_gemma":0.0002782686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001628457,"about_ca_topic_score_gemma":0.003190656,"domain_scores_codex":[0.9997883,0.00003410326,0.00001334881,0.00006384398,0.00005654646,0.0000438939],"domain_scores_gemma":[0.9997842,0.00003462916,0.00005304422,0.00004210755,0.00003098368,0.00005509665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002168567,0.0001149739,0.001142176,0.00004900151,0.00001172674,0.0002445288,0.00006273064,0.0001415557,0.9924611,0.0004309995,0.0002932421,0.004831058],"study_design_scores_gemma":[0.00009884432,0.004090154,0.02038892,0.00006739273,0.0001179297,0.004053649,0.0001601268,0.004601702,0.9416568,0.0006745037,0.02405853,0.00003141654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768786,0.001605306,0.01542654,0.0003677241,0.0000815247,0.0003123436,0.001357051,0.0004407305,0.003530222],"genre_scores_gemma":[0.9831717,0.0007683461,0.009976965,0.0002163502,0.00001733137,0.0003665792,0.0009095009,0.00006848964,0.004504678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002242714,"threshold_uncertainty_score":0.007502615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08343526588746084,"score_gpt":0.3426128571762473,"score_spread":0.2591775912887865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}