{"id":"W4283079234","doi":"10.3390/pathogens11060693","title":"Probe Capture Enrichment Methods for HIV and HCV Genome Sequencing and Drug Resistance Genotyping","year":2022,"lang":"en","type":"review","venue":"Pathogens","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Sanger sequencing; Genotyping; Biology; Massive parallel sequencing; DNA sequencing; Genome; Computational biology; Whole genome sequencing; Virology; Deep sequencing; Genetics; DNA; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001032062,0.000545575,0.001662157,0.0002367211,0.0003291031,0.00003979439,0.0001024853,0.0001575587,0.00008356905],"category_scores_gemma":[0.00012111,0.0004305791,0.0002668923,0.0002522385,0.00004987586,0.00003678172,0.0001751685,0.0003400864,0.00000527611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007481945,"about_ca_system_score_gemma":0.0005241285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002430973,"about_ca_topic_score_gemma":0.000007773589,"domain_scores_codex":[0.9976673,0.0002658747,0.0005868104,0.0008235989,0.0002103482,0.0004460537],"domain_scores_gemma":[0.9986553,0.0004130317,0.0002908448,0.0003720446,0.00004769218,0.0002211299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003372102,0.00005645682,0.00003050719,0.03258777,0.0008406235,0.0001974608,0.004068584,1.847178e-7,0.00008132965,0.0003856468,0.0006895047,0.9610282],"study_design_scores_gemma":[0.0005356073,0.00001890373,0.000005977128,0.002203267,0.00251031,0.0001310169,0.0002458785,0.000006619443,0.000003834883,0.00009036113,0.9938431,0.000405169],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000059463,0.9915348,0.003453292,0.0003489463,0.0001174828,0.003140591,0.0001933366,0.00006690202,0.001138652],"genre_scores_gemma":[8.273472e-7,0.7611469,0.2099277,0.00006945487,0.00009903776,0.001139469,0.0005693441,0.000080405,0.02696684],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9931536,"threshold_uncertainty_score":0.9998146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05571146625448847,"score_gpt":0.3533919128151366,"score_spread":0.2976804465606481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}