{"id":"W4283080702","doi":"10.1016/j.neuro.2022.06.004","title":"Ketamine-induced neurotoxicity is mediated through endoplasmic reticulum stress in vitro in STHdhQ7/Q7 cells","year":2022,"lang":"en","type":"article","venue":"NeuroToxicology","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Viability assay; Unfolded protein response; Endoplasmic reticulum; Neurotoxicity; XBP1; ATF4; Cell biology; MTT assay; Biology; Programmed cell death; Chemistry; Pharmacology; Cell; Apoptosis; Biochemistry; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004031884,0.0004301147,0.0005605278,0.000243961,0.0004024599,0.0004076069,0.0003989207,0.0003729042,0.001960309],"category_scores_gemma":[0.0001971658,0.0002674683,0.0006936186,0.000331612,0.0003154697,0.0006414467,0.0003194572,0.001146015,0.001083007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003254144,"about_ca_system_score_gemma":0.000358149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00235837,"about_ca_topic_score_gemma":0.003174298,"domain_scores_codex":[0.9995418,0.00007941826,0.00008281782,0.00007288002,0.0001154409,0.0001076495],"domain_scores_gemma":[0.9997875,0.00004136176,0.0000440649,0.00005175365,0.00004447654,0.00003078192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003986703,0.0001242833,0.0004017301,0.00007613224,0.00001695362,0.0001748628,0.0001039271,0.00006284712,0.9975095,0.0002330373,0.0001421011,0.0007558767],"study_design_scores_gemma":[0.00007902645,0.0009490317,0.01184652,0.00002407136,0.00006369877,0.0004301456,0.0002950333,0.001517029,0.981204,0.0001618643,0.003411453,0.00001816863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987527,0.002391048,0.004812353,0.0003851593,0.0001811667,0.00006542316,0.001667256,0.00009693779,0.002873743],"genre_scores_gemma":[0.9847179,0.002250636,0.004081793,0.0001425065,0.00004306892,0.00009092787,0.003331793,0.00003942883,0.005301955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00235837,"threshold_uncertainty_score":0.006557882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0514430645339096,"score_gpt":0.2990867498955066,"score_spread":0.247643685361597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}