{"id":"W4283124474","doi":"10.1021/acschembio.2c00378","title":"Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Structural Genomics Consortium; Montreal Neurological Institute and Hospital","funders":"National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec; Parkinson Society Canada; North Carolina General Assembly; Takeda Pharmaceutical Company; North Carolina Biotechnology Center; Graduate School, University of North Carolina at Chapel Hill; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Coronavirus; Biology; Virology; Viral entry; Gene knockdown; Viral replication; Endocytosis; Kinase; Cell biology; Cell culture; Coronavirus disease 2019 (COVID-19); Cell; Virus; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001188105,0.0005017478,0.0003173735,0.0001785351,0.0001942211,0.0003598908,0.0001640673,0.0001767807,0.001863941],"category_scores_gemma":[0.0000972534,0.0001470242,0.0002465573,0.0001717167,0.0001908967,0.0002550507,0.0001500692,0.0005755306,0.0004325508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004468277,"about_ca_system_score_gemma":0.0003990866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006378292,"about_ca_topic_score_gemma":0.001789228,"domain_scores_codex":[0.9999295,0.000008215673,0.000006982692,0.00001597095,0.00002005818,0.00001922842],"domain_scores_gemma":[0.9999586,0.000005422582,0.00001018366,0.00000426242,0.000008307615,0.00001315544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003101188,0.00003180684,0.000239842,0.0000631017,0.000009059539,0.00002789561,0.000008170839,0.0002582205,0.9969626,0.000132503,0.0001164635,0.001840277],"study_design_scores_gemma":[0.00005530287,0.0004175557,0.002949668,0.000008707853,0.0000205772,0.0003446591,0.00002142117,0.001256284,0.9892587,0.00006413141,0.005595815,0.000007205411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839745,0.005408064,0.003192085,0.000308892,0.00009690972,0.00006081975,0.0008386964,0.0001007768,0.006019367],"genre_scores_gemma":[0.9902588,0.002692978,0.002208812,0.00007595769,0.00001659707,0.00004537229,0.0009736615,0.00002037043,0.003707375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001863941,"threshold_uncertainty_score":0.00623548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0467883306412404,"score_gpt":0.349302841850218,"score_spread":0.3025145112089776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}