{"id":"W4283124474","doi":"10.1021/acschembio.2c00378","title":"Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Structural Genomics Consortium; Montreal Neurological Institute and Hospital","funders":"National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec; Parkinson Society Canada; North Carolina General Assembly; Takeda Pharmaceutical Company; North Carolina Biotechnology Center; Graduate School, University of North Carolina at Chapel Hill; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Coronavirus; Biology; Virology; Viral entry; Gene knockdown; Viral replication; Endocytosis; Kinase; Cell biology; Cell culture; Coronavirus disease 2019 (COVID-19); Cell; Virus; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002229927,0.0001298015,0.0003306723,0.00009542625,0.00006318397,0.000003078977,0.0001436896,0.0001461874,0.0001161872],"category_scores_gemma":[0.0002571631,0.0001162086,0.0001604345,0.0002245854,0.0001910149,0.00002246367,0.0002377294,0.0002609753,0.00001995948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001046481,"about_ca_system_score_gemma":0.0001601949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000546163,"about_ca_topic_score_gemma":0.000001182943,"domain_scores_codex":[0.9988008,0.00005469129,0.0002822512,0.0003562078,0.0001612929,0.0003447867],"domain_scores_gemma":[0.9993007,0.0002091026,0.0000781223,0.0002748802,0.0001027052,0.00003450704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009220246,0.0002638881,0.008767215,0.00007301109,0.00004578061,0.00001609134,0.00009898119,1.518877e-8,0.9848288,0.0002246606,0.002930896,0.001828633],"study_design_scores_gemma":[0.001573096,0.0007371254,0.0001557654,0.000008352326,0.00002871749,0.00002926719,0.00004944078,0.00001504833,0.8150097,0.001208637,0.1810887,0.00009610307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973615,0.0006263772,0.00005589617,0.0007343827,0.00009715236,0.0004409747,0.0004167933,0.00003608898,0.0002307642],"genre_scores_gemma":[0.9605693,0.000006522544,0.0003702115,0.03845228,0.0001153987,0.0002749478,0.0001735126,0.00002046028,0.00001736965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1781579,"threshold_uncertainty_score":0.4738849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0467883306412404,"score_gpt":0.349302841850218,"score_spread":0.3025145112089776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}