{"id":"W4283155695","doi":"10.1016/j.cmet.2022.06.003","title":"Metabolic cycles and signals for insulin secretion","year":2022,"lang":"en","type":"review","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Biomedical Laboratory Research and Development, VA Office of Research and Development; University of Pennsylvania; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Oxidative phosphorylation; Metabolic pathway; Biology; Secretion; Nutrient sensing; Cell biology; Insulin; Glucose homeostasis; Metabolism; Signal transduction; Biochemistry; Endocrinology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004903371,0.0004229297,0.002547372,0.0003486891,0.0001423767,0.00003595922,0.0001065821,0.0002405805,0.001406373],"category_scores_gemma":[0.000333038,0.0003303465,0.0006029056,0.0003156184,0.00005912249,0.00005421021,0.00007852979,0.000340695,0.00005740076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002695683,"about_ca_system_score_gemma":0.0002473577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008278504,"about_ca_topic_score_gemma":1.174478e-7,"domain_scores_codex":[0.998168,0.0001842455,0.0005722924,0.0005043771,0.0002599199,0.0003111545],"domain_scores_gemma":[0.9984944,0.0005264285,0.0003204347,0.0003772028,0.00005152381,0.0002299845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002307015,0.00008677387,0.000001833801,0.01214457,0.0002434234,0.000003641215,0.00005199433,1.759093e-7,0.00007747304,0.0006956875,0.001823904,0.9848474],"study_design_scores_gemma":[0.001029579,0.00005350474,0.00002307668,0.0006468235,0.006785139,0.00002473788,0.00003595529,0.00001475565,0.0001233221,0.0001938357,0.9907793,0.0002899017],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001521827,0.9929608,0.00008443756,0.00002860377,0.0007367386,0.00168469,0.0001638679,0.00009117309,0.004097474],"genre_scores_gemma":[0.00001042433,0.9923936,0.0009774307,0.0003205218,0.0007449721,0.0009147945,0.0006875974,0.0000909899,0.00385963],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9889554,"threshold_uncertainty_score":0.9999149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05725899689099058,"score_gpt":0.3163061839949222,"score_spread":0.2590471871039317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}