{"id":"W4283155695","doi":"10.1016/j.cmet.2022.06.003","title":"Metabolic cycles and signals for insulin secretion","year":2022,"lang":"en","type":"review","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Biomedical Laboratory Research and Development, VA Office of Research and Development; University of Pennsylvania; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Oxidative phosphorylation; Metabolic pathway; Biology; Secretion; Nutrient sensing; Cell biology; Insulin; Glucose homeostasis; Metabolism; Signal transduction; Biochemistry; Endocrinology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006190794,0.001413018,0.001459001,0.001855713,0.0002525156,0.001679866,0.000812345,0.001279605,0.00442936],"category_scores_gemma":[0.0007853875,0.0003313415,0.0004020852,0.002385233,0.0007816803,0.001863647,0.001103645,0.002403955,0.002751346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007923624,"about_ca_system_score_gemma":0.001004349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007043207,"about_ca_topic_score_gemma":0.001229862,"domain_scores_codex":[0.9998544,0.00002941229,0.00002113959,0.00002725557,0.00004728232,0.00002040737],"domain_scores_gemma":[0.9997979,0.0001005357,0.00003437414,0.000007208669,0.00003553605,0.00002459783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001939434,0.00005993411,0.0001810813,0.01237019,0.00008344001,0.0001978419,0.00005358894,0.0004821552,0.00157656,0.009177662,0.04575606,0.9298675],"study_design_scores_gemma":[0.0000310862,0.0000615008,0.0005694862,0.002688291,0.00009832864,0.000492021,0.0000501127,0.0001184539,0.0003187434,0.005637865,0.9899151,0.00001891951],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006517616,0.9979627,0.000144731,0.0003293096,0.0004492757,0.000003327754,0.00001776132,0.00000722238,0.0010205],"genre_scores_gemma":[0.0004420028,0.9981328,0.0001232119,0.0002466075,0.0004679211,0.000005244199,0.00002911018,0.000001331928,0.00055183],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00442936,"threshold_uncertainty_score":0.01481771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05725899689099058,"score_gpt":0.3163061839949222,"score_spread":0.2590471871039317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}