{"id":"W4283157118","doi":"10.1042/cs20211180","title":"Defining the molecular underpinnings controlling cardiomyocyte proliferation","year":2022,"lang":"en","type":"review","venue":"Clinical Science","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Canadian Heart Research Centre; University of Toronto; Canada Research Chairs; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; Biology; Cell cycle; E2F; PI3K/AKT/mTOR pathway; Cell biology; Transcription factor; Cyclin-dependent kinase; Protein kinase B; Cell growth; microRNA; Cancer research; Signal transduction; Bioinformatics; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004951655,0.0004267994,0.0004066227,0.0005638446,0.0003298312,0.001195141,0.0005824218,0.0007323131,0.001092778],"category_scores_gemma":[0.000396815,0.0002343181,0.000264417,0.0003497806,0.001098228,0.001083675,0.0007517342,0.00147503,0.0005715771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006681997,"about_ca_system_score_gemma":0.0009035002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006670182,"about_ca_topic_score_gemma":0.0007740559,"domain_scores_codex":[0.9997479,0.00002832294,0.00002586089,0.00007789356,0.00006825409,0.00005170227],"domain_scores_gemma":[0.999819,0.00004761603,0.00005940736,0.00001189391,0.00003827556,0.00002394351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002665981,0.00005538663,0.002349466,0.003717734,0.00006559629,0.002020115,0.0004777534,0.002251422,0.7204186,0.1277883,0.003402274,0.1371866],"study_design_scores_gemma":[0.00005647386,0.000636884,0.0332862,0.001468602,0.0001779321,0.006189792,0.000959194,0.006310127,0.3623577,0.09687678,0.4915439,0.0001365329],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09838008,0.7681218,0.08132552,0.006101068,0.001574409,0.0001673844,0.0009799605,0.000408349,0.04294138],"genre_scores_gemma":[0.4501895,0.5206757,0.01649691,0.001371101,0.001421917,0.0002572375,0.0007580284,0.00006516313,0.008764495],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001195141,"threshold_uncertainty_score":0.004848123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08017256208059019,"score_gpt":0.448254314209068,"score_spread":0.3680817521284778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}