{"id":"W4283158668","doi":"10.1038/s41467-022-31124-7","title":"EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Anschutz Medical Campus, University of Colorado; National Jewish Health; Cancer Center, University of Colorado","keywords":"Head and neck squamous-cell carcinoma; Tumor microenvironment; Cancer research; Angiogenesis; Cancer cell; Downregulation and upregulation; Suppressor; Cancer; Biology; Cell biology; Head and neck cancer; Tumor cells; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295338,0.0001599267,0.0002115361,0.0001237417,0.0001484072,0.0003607704,0.0001027219,0.0002075625,0.0009952603],"category_scores_gemma":[0.00008853411,0.0001455211,0.0001237504,0.00008165329,0.0002493271,0.0002172248,0.0003426782,0.0002681694,0.0002227986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002778598,"about_ca_system_score_gemma":0.0003058258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004075045,"about_ca_topic_score_gemma":0.000852836,"domain_scores_codex":[0.9998608,0.00003317578,0.000005884526,0.00001854915,0.00003820047,0.00004347065],"domain_scores_gemma":[0.9999639,0.000005717987,0.00001043956,0.000003296353,0.000004812746,0.00001181377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000113742,0.000008561079,0.0005605983,0.00001568875,0.000004682364,0.0000471265,0.000007691063,0.0001415412,0.9973373,0.0002330924,0.00002554918,0.00150445],"study_design_scores_gemma":[0.00003422534,0.0005173918,0.02318207,0.00001038686,0.00003585014,0.0007064706,0.00023234,0.002805051,0.9676088,0.0004820717,0.00437544,0.000009831129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947197,0.001154284,0.001901453,0.000118525,0.00001341332,0.00001216598,0.00006461501,0.00002463762,0.001991175],"genre_scores_gemma":[0.9956125,0.001020319,0.001715665,0.00005400669,0.000005804971,0.00002081685,0.00005557002,0.00000720667,0.001508078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009952603,"threshold_uncertainty_score":0.003329456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03797133901174978,"score_gpt":0.3021243634906643,"score_spread":0.2641530244789145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}