{"id":"W4283159318","doi":"10.1007/s40120-022-00373-5","title":"The Potential Economic Value of Lecanemab in Patients with Early Alzheimer’s Disease Using Simulation Modeling","year":2022,"lang":"en","type":"article","venue":"Neurology and Therapy","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Eisai","keywords":"Willingness to pay; Medicine; Disease; Quality of life (healthcare); Health care; Quality-adjusted life year; Neurology; Gerontology; Psychiatry; Internal medicine; Cost effectiveness; Economics; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001235043,0.00004982027,0.00007958432,0.00005538408,0.0001443401,0.000005450533,0.00003499106,0.00001343094,0.00003547416],"category_scores_gemma":[0.000002971388,0.00003521853,0.00001854181,0.00003811451,0.00005181328,0.000033447,0.00002757872,0.0001250085,3.052226e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006320001,"about_ca_system_score_gemma":0.00005564806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005203865,"about_ca_topic_score_gemma":0.000001679581,"domain_scores_codex":[0.9994218,0.0001274092,0.00009893515,0.0001213071,0.0001121205,0.0001184012],"domain_scores_gemma":[0.9997994,0.00003741402,0.00003218176,0.00007488018,0.00002272541,0.00003334366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009548123,0.0001363414,0.8425597,0.000001811536,0.00004807068,0.000008234951,0.00005344382,0.1417384,0.00005380114,0.00005454838,4.78865e-7,0.005797047],"study_design_scores_gemma":[0.002753322,0.001223846,0.6638583,0.000001374924,0.00002469991,0.000001184464,0.000007937977,0.3318421,0.00001122749,0.0002223261,0.00002753471,0.00002616006],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988952,0.000336299,0.0001048501,0.0002661248,0.00004333324,0.0003251621,0.000003882434,0.000003846831,0.00002132455],"genre_scores_gemma":[0.9996387,0.00004706307,0.000004636346,0.0002655939,0.00001356827,0.00001250543,0.000006591292,0.000007266348,0.000004058619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1901037,"threshold_uncertainty_score":0.143617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01945440523287799,"score_gpt":0.2891524206259576,"score_spread":0.2696980153930796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}