{"id":"W4283167323","doi":"10.1186/s43682-022-00012-y","title":"Smoking and colorectal cancer survival in relation to tumor LINE-1 methylation levels: a prospective cohort study","year":2022,"lang":"en","type":"article","venue":"Epigenetics Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mishima Kaiun Memorial Foundation; National Institutes of Health; Orionin Tutkimussäätiö; Suomen Kulttuurirahasto; National Natural Science Foundation of China; Stand Up To Cancer; China Scholarship Council; Uehara Memorial Foundation; Entertainment Industry Foundation; Mitsukoshi Health and Welfare Foundation; American Association for Cancer Research; American Society of Clinical Oncology; Massachusetts General Hospital; Conquer Cancer Foundation; Colorectal Cancer Alliance; Gary Bennett Family Fund; Dana-Farber/Harvard Cancer Center; Japan Society for the Promotion of Science; Prevent Cancer Foundation","keywords":"Colorectal cancer; Medicine; Oncology; Hazard ratio; Prospective cohort study; Internal medicine; Proportional hazards model; DNA methylation; Confounding; Cancer; Methylation; Cohort; Confidence interval; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001034918,0.0001345694,0.0002320462,0.0002351989,0.0008402167,0.0000200851,0.0004337713,0.0000530739,0.0002394322],"category_scores_gemma":[0.0001216942,0.0001520871,0.00003286164,0.0004830351,0.0001089331,0.00005723702,0.0005780935,0.0005083199,0.00001239232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000236249,"about_ca_system_score_gemma":0.00011086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004457,"about_ca_topic_score_gemma":0.001223654,"domain_scores_codex":[0.9976333,0.001469792,0.0003706528,0.0002527705,0.00006954981,0.0002038765],"domain_scores_gemma":[0.9987462,0.0004319382,0.0001226554,0.0006044034,0.00008099979,0.0000138676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003234661,0.0005747784,0.8882334,0.00000220988,0.0002309254,7.080988e-7,0.01047534,0.0009484367,0.09415389,0.0004907788,0.00002358871,0.004542439],"study_design_scores_gemma":[0.00105931,0.0004596177,0.9848281,0.00000934052,0.00004362065,0.000005760277,0.002587778,0.00009512737,0.005082041,0.0001609437,0.005495189,0.0001731883],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873807,0.009597057,0.0001469492,0.0006268161,0.0002594882,0.001489421,0.00005987681,0.0000411703,0.0003985221],"genre_scores_gemma":[0.9974439,0.0003315433,0.0002695456,0.00006867143,0.000006997456,0.001347973,0.00006130538,0.00002186399,0.0004482406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09659465,"threshold_uncertainty_score":0.6462352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0468276596489941,"score_gpt":0.3257674572649016,"score_spread":0.2789397976159075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}