{"id":"W4283167323","doi":"10.1186/s43682-022-00012-y","title":"Smoking and colorectal cancer survival in relation to tumor LINE-1 methylation levels: a prospective cohort study","year":2022,"lang":"en","type":"article","venue":"Epigenetics Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mishima Kaiun Memorial Foundation; National Institutes of Health; Orionin Tutkimussäätiö; Suomen Kulttuurirahasto; National Natural Science Foundation of China; Stand Up To Cancer; China Scholarship Council; Uehara Memorial Foundation; Entertainment Industry Foundation; Mitsukoshi Health and Welfare Foundation; American Association for Cancer Research; American Society of Clinical Oncology; Massachusetts General Hospital; Conquer Cancer Foundation; Colorectal Cancer Alliance; Gary Bennett Family Fund; Dana-Farber/Harvard Cancer Center; Japan Society for the Promotion of Science; Prevent Cancer Foundation","keywords":"Colorectal cancer; Medicine; Oncology; Hazard ratio; Prospective cohort study; Internal medicine; Proportional hazards model; DNA methylation; Confounding; Cancer; Methylation; Cohort; Confidence interval; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001036093,0.0003273658,0.0003222285,0.0005864042,0.0004688775,0.000702228,0.0003933955,0.0005308889,0.001266015],"category_scores_gemma":[0.001833727,0.0004225149,0.0006783278,0.001122592,0.0002116415,0.0003660774,0.0004157654,0.0007126334,0.0001812227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219814,"about_ca_system_score_gemma":0.0003212141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007068884,"about_ca_topic_score_gemma":0.007153973,"domain_scores_codex":[0.9994676,0.0001659431,0.00005169861,0.0001565558,0.00007151507,0.00008680658],"domain_scores_gemma":[0.9983538,0.0003047734,0.0005161006,0.0003027401,0.0002001734,0.0003223798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001888041,0.00003226722,0.9989104,0.000005406622,0.0001589864,0.00003299697,0.00002430488,0.00002686485,0.0002082402,0.000008983105,0.0000438255,0.0003589801],"study_design_scores_gemma":[0.00001588044,0.0001067884,0.9991311,0.000004038246,0.0001278682,0.0001173901,0.00004565433,0.0002639141,0.00006165995,0.00001611167,0.0001052347,0.00000425201],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990527,0.0002550992,0.0001385389,0.00002688657,0.000006384196,0.00000794676,0.0003864257,0.000003700549,0.0001221472],"genre_scores_gemma":[0.999446,0.00008580436,0.00009193515,0.00001548791,0.000006686597,0.000007871459,0.0002584589,0.000001825709,0.00008595407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007068884,"threshold_uncertainty_score":0.01405543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0468276596489941,"score_gpt":0.3257674572649016,"score_spread":0.2789397976159075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}