{"id":"W4283169331","doi":"10.1007/s40268-022-00391-6","title":"Analysis of the US Safety Data for Edaravone (Radicava®) From the Third Year After Launch","year":2022,"lang":"en","type":"article","venue":"Drugs in R&D","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Medicine; Adverse effect; Edaravone; Amyotrophic lateral sclerosis; Postmarketing surveillance; Clinical trial; Disease; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006419301,0.000332674,0.0004788817,0.002458987,0.0003085733,0.0009585028,0.0004136886,0.0003820826,0.004086641],"category_scores_gemma":[0.01326209,0.0002144986,0.00163795,0.003727363,0.0002575043,0.0005249425,0.0005373133,0.000896944,0.001068287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001567296,"about_ca_system_score_gemma":0.003363385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005959238,"about_ca_topic_score_gemma":0.006080484,"domain_scores_codex":[0.9947723,0.0009192188,0.001102558,0.0005335509,0.00234958,0.0003227909],"domain_scores_gemma":[0.9701219,0.00578788,0.01505089,0.001177604,0.007302123,0.0005595801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009683916,0.0003671471,0.7866771,0.002816094,0.002479119,0.0006105101,0.0003524169,0.002243656,0.003090901,0.0008523866,0.04600245,0.1448243],"study_design_scores_gemma":[0.0004297675,0.001900561,0.9113677,0.0008664735,0.001187284,0.001407899,0.0002508206,0.001845961,0.004262984,0.0004129571,0.07600419,0.00006348098],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7267733,0.02002548,0.004953446,0.002148149,0.000272528,0.001105895,0.2246949,0.0004881232,0.01953809],"genre_scores_gemma":[0.8469249,0.00621631,0.00199325,0.001657491,0.0002010258,0.0008350242,0.1388892,0.0001067249,0.003176107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006419301,"threshold_uncertainty_score":0.0339489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03374131150750272,"score_gpt":0.3130737246580986,"score_spread":0.2793324131505959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}