{"id":"W4283171120","doi":"10.1016/j.isci.2022.104646","title":"The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondation de l'École Polytechnique; Centre National de la Recherche Scientifique; Universität zu Köln; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; China Scholarship Council; Rockefeller University; McGill University","keywords":"Gene silencing; microRNA; Psychological repression; Biology; RNA interference; Function (biology); Cell biology; Regulation of gene expression; Gene expression; Gene; Computational biology; Genetics; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002508058,0.0003343414,0.0002571925,0.0001490836,0.0001105607,0.0002382442,0.0001596623,0.0002652697,0.001432923],"category_scores_gemma":[0.0001494955,0.000119754,0.0002278271,0.00007636483,0.0002045036,0.0001152913,0.0001888551,0.000358823,0.000381954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002449399,"about_ca_system_score_gemma":0.0001761685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000682404,"about_ca_topic_score_gemma":0.0005688231,"domain_scores_codex":[0.999778,0.00006175026,0.00003151195,0.00003651548,0.0000568793,0.00003545397],"domain_scores_gemma":[0.9999089,0.00002496298,0.00001723918,0.00001579333,0.000006389052,0.00002659286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006893378,0.00002105767,0.00009308098,0.00001003628,0.000004039003,0.00003597861,0.000006521446,0.00004164598,0.9993899,0.00004454402,0.00002196398,0.0002622601],"study_design_scores_gemma":[0.00001137651,0.0002193321,0.002318066,0.000002000923,0.000005282318,0.0002240838,0.00001621786,0.001344768,0.9948487,0.00003231069,0.0009751869,0.00000252215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970096,0.0004326931,0.00151163,0.00006950947,0.00001853087,0.00001278969,0.0002666029,0.00004161234,0.000636916],"genre_scores_gemma":[0.9951127,0.0002001773,0.001368641,0.00004901842,0.000005865838,0.00002496959,0.000847707,0.00002166695,0.002369327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432923,"threshold_uncertainty_score":0.004793584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04164989830803484,"score_gpt":0.2794817255130513,"score_spread":0.2378318272050165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}