{"id":"W4283206312","doi":"10.1016/j.actbio.2022.06.030","title":"In Vitro Cytotoxicity and Cytokine Production by Lipid-Substituted Low Molecular Weight Branched PEIs Used for Gene Delivery","year":2022,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Alex's Lemonade Stand Foundation for Childhood Cancer; Bill and Melinda Gates Foundation","keywords":"Cytotoxicity; In vitro; Gene delivery; Materials science; Cytokine; Gene; Biochemistry; Biology; Immunology; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001961936,0.0002063179,0.000212268,0.00008076629,0.0001316285,0.00004379306,0.0001989196,0.0001216803,0.00004667805],"category_scores_gemma":[0.00003124719,0.0002199314,0.00006856535,0.0001214956,0.00006082547,0.00001710418,0.0001822829,0.00005023923,0.000002377964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004202051,"about_ca_system_score_gemma":0.00004633735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001012046,"about_ca_topic_score_gemma":0.00001427555,"domain_scores_codex":[0.9986753,0.00009495964,0.000267235,0.0005484505,0.0001254713,0.0002886024],"domain_scores_gemma":[0.9994698,0.000004526198,0.0001026748,0.000307469,0.00005292365,0.00006256386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000847663,0.0001171105,0.00009802985,0.00002842895,0.00005398467,0.000008333169,0.00007973688,0.000006282283,0.9918027,0.000001772817,0.006872514,0.00008347939],"study_design_scores_gemma":[0.001063117,0.0002200698,0.0002465447,0.000005720217,0.00002059293,0.00003364044,0.00002629483,0.00003832798,0.9877695,0.0000187265,0.01029077,0.0002666824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969744,0.0002153511,0.0001774001,0.0004226779,0.001118235,0.0004746403,0.0005945127,0.0000190482,0.000003697724],"genre_scores_gemma":[0.9970349,0.0000878288,0.0002773418,0.0003091555,0.0002939664,0.0002372527,0.001565009,0.00003002509,0.000164489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004033151,"threshold_uncertainty_score":0.8968543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006610690431775678,"score_gpt":0.22363739457893,"score_spread":0.2170267041471544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}