{"id":"W4283206312","doi":"10.1016/j.actbio.2022.06.030","title":"In Vitro Cytotoxicity and Cytokine Production by Lipid-Substituted Low Molecular Weight Branched PEIs Used for Gene Delivery","year":2022,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Alex's Lemonade Stand Foundation for Childhood Cancer; Bill and Melinda Gates Foundation","keywords":"Cytotoxicity; In vitro; Gene delivery; Materials science; Cytokine; Gene; Biochemistry; Biology; Immunology; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005424581,0.0005422762,0.0003661814,0.0002508567,0.0001834654,0.000305883,0.0002100749,0.0004577344,0.0009560279],"category_scores_gemma":[0.0003607558,0.0002022083,0.0004093186,0.0002943282,0.000327817,0.0002973475,0.0001879981,0.0005750032,0.0003204229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002285821,"about_ca_system_score_gemma":0.0002124164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003947496,"about_ca_topic_score_gemma":0.000376802,"domain_scores_codex":[0.9996213,0.0001025933,0.00006605253,0.00004336753,0.00009265178,0.00007406087],"domain_scores_gemma":[0.9994405,0.0002796453,0.00009971725,0.00005216483,0.00008586283,0.00004201379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003190111,0.00004193216,0.0001311141,0.00006404168,0.0000069934,0.00005887161,0.00003490403,0.0002012726,0.9985332,0.00004086517,0.00001078399,0.0005569816],"study_design_scores_gemma":[0.000009616895,0.0003740947,0.0004615956,0.000002594882,0.000009132827,0.00003936243,0.00000762495,0.0002862084,0.9986406,0.00001255407,0.0001543169,0.000002180337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938135,0.00165624,0.003221831,0.00003794724,0.00003916779,0.00002657846,0.0002333848,0.00003308652,0.0009381392],"genre_scores_gemma":[0.9949065,0.0008481859,0.001911095,0.00002756552,0.00001386417,0.00004750904,0.0003619014,0.0000151269,0.001868268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009560279,"threshold_uncertainty_score":0.003198206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006610690431775678,"score_gpt":0.22363739457893,"score_spread":0.2170267041471544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}