{"id":"W4283213156","doi":"10.2174/1389200223666220621113524","title":"Relevance of ABC Transporters in Drug Development","year":2022,"lang":"en","type":"review","venue":"Current Drug Metabolism","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Toronto","funders":"","keywords":"ATP-binding cassette transporter; Abcg2; Transporter; P-glycoprotein; Drug; Pharmacology; Multiple drug resistance; Drug resistance; In vivo; Biology; Xenobiotic; Computational biology; Biochemistry; Biotechnology; Genetics; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008595858,0.00074713,0.003905504,0.0007781398,0.00008627041,0.000008345552,0.0005088761,0.0001444353,0.0005348307],"category_scores_gemma":[0.00002560228,0.0006088097,0.0009974007,0.001045402,0.0001025792,0.00007876708,0.00004713422,0.001286548,0.00002617846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002124683,"about_ca_system_score_gemma":0.001302071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000127243,"about_ca_topic_score_gemma":0.00004602274,"domain_scores_codex":[0.9955016,0.000156022,0.001958654,0.0008181924,0.0009656388,0.0005998663],"domain_scores_gemma":[0.9982641,0.0001070812,0.0006565499,0.0006871914,0.00005381084,0.0002312569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003564596,0.0004298494,0.000009698739,0.03848439,0.0001536445,0.00008890693,0.001389339,0.000001318628,0.000002231978,0.0003855749,0.0005043666,0.958515],"study_design_scores_gemma":[0.0009550767,0.000005697469,0.00005793875,0.01606828,0.001496198,0.00001094834,0.0001565453,6.178387e-7,0.00007766175,0.0000398206,0.9806018,0.000529412],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003903871,0.9936413,0.00005437711,0.000029599,0.003411385,0.001613634,0.0001085104,0.00006651916,0.0006842876],"genre_scores_gemma":[0.00009265045,0.9960282,0.0006710925,0.00002326385,0.0002253135,0.0004524606,0.0009045316,0.0001250186,0.001477441],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9800974,"threshold_uncertainty_score":0.9996364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05349451340919847,"score_gpt":0.3277920366821583,"score_spread":0.2742975232729598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}