{"id":"W4283216044","doi":"10.1158/2159-8290.cd-20-1628","title":"IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma","year":2022,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Cytotoxic T cell; Innate immune system; Cancer research; Immunology; Biology; Immune checkpoint; Tumor microenvironment; Immunotherapy; Immune system; Hepatocellular carcinoma; Cancer; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002536517,0.0002364525,0.0003617436,0.0001160934,0.0003593243,0.00008291523,0.0002659028,0.00005301054,0.0009023374],"category_scores_gemma":[0.00003291965,0.000221085,0.0002541466,0.0002505586,0.00004106913,0.0003512383,0.0002286529,0.0002888727,0.00001782722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006422453,"about_ca_system_score_gemma":0.0004084227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208564,"about_ca_topic_score_gemma":0.00004591639,"domain_scores_codex":[0.998369,0.00005462115,0.0003711425,0.0005359655,0.0002632023,0.0004060126],"domain_scores_gemma":[0.9989924,0.00003347657,0.0001346604,0.0005633521,0.0001149625,0.0001611094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006800754,0.0002630691,0.001671541,0.00009601239,0.0000959196,0.00004889796,0.0009892959,0.0006631647,0.9940208,0.000176217,0.0003870014,0.0009080342],"study_design_scores_gemma":[0.001127124,0.002586144,0.0006473654,0.0001320485,0.0001349854,0.00004998392,0.001512766,0.003086941,0.9626793,0.0002195329,0.02748692,0.000336879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994561,0.001231892,0.0004438295,0.0007878002,0.0008672481,0.001402693,0.0003820299,0.00009276778,0.0002307151],"genre_scores_gemma":[0.9944287,0.00004447058,0.0004815445,0.001306329,0.0003721112,0.001412154,0.000129184,0.0000645636,0.001760945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03134147,"threshold_uncertainty_score":0.9879962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03494907069737944,"score_gpt":0.2956631358578674,"score_spread":0.260714065160488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}