{"id":"W4283220921","doi":"10.1097/cmr.0000000000000810","title":"Exceptional response to combination ipilimumab and nivolumab in metastatic uveal melanoma: Insights from genomic analysis","year":2022,"lang":"en","type":"article","venue":"Melanoma Research","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada Research Chairs; University of Toronto; Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Nivolumab; Ipilimumab; Melanoma; Metastatic melanoma; Medicine; Cancer research; Oncology; Internal medicine; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001694696,0.0001584105,0.0002859263,0.0005235843,0.0001758309,0.0003901616,0.0001427809,0.0002809072,0.0004847661],"category_scores_gemma":[0.000436773,0.0001051729,0.0002985923,0.0005596784,0.0001766125,0.0001221592,0.0001918004,0.0002865999,0.0001141267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001855008,"about_ca_system_score_gemma":0.00009153527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005306904,"about_ca_topic_score_gemma":0.0007907475,"domain_scores_codex":[0.9998553,0.0000217846,0.000009980436,0.00005386021,0.00003423384,0.00002482805],"domain_scores_gemma":[0.9998098,0.00006074536,0.00007264287,0.0000145282,0.00001987455,0.00002249948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"case_report","study_design_scores_codex":[0.001134297,0.0001270313,0.4865084,0.0003695076,0.0004486016,0.02274805,0.0005606419,0.002303256,0.4187803,0.0004890069,0.00123511,0.06529587],"study_design_scores_gemma":[0.00002287114,0.0002318385,0.9475651,0.00003362606,0.0003243485,0.02154003,0.0003175996,0.004429002,0.02024943,0.0006235692,0.004639357,0.00002328925],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959272,0.001631588,0.001254451,0.0001686687,0.000007232713,0.000009157168,0.0005267029,0.00003593649,0.0004389838],"genre_scores_gemma":[0.9976514,0.0005239184,0.001069887,0.00007793136,0.0000139307,0.000005550385,0.0005119998,0.00001189386,0.0001335271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005306904,"threshold_uncertainty_score":0.001621723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04636021055271448,"score_gpt":0.3625567493310642,"score_spread":0.3161965387783497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}