{"id":"W4283220921","doi":"10.1097/cmr.0000000000000810","title":"Exceptional response to combination ipilimumab and nivolumab in metastatic uveal melanoma: Insights from genomic analysis","year":2022,"lang":"en","type":"article","venue":"Melanoma Research","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada Research Chairs; University of Toronto; Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Nivolumab; Ipilimumab; Melanoma; Metastatic melanoma; Medicine; Cancer research; Oncology; Internal medicine; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00147911,0.0001286201,0.0003955618,0.00164197,0.0003772987,0.00002526937,0.0001410789,0.00005906219,0.001104958],"category_scores_gemma":[0.000205264,0.0001244198,0.0000827465,0.001520452,0.0001050683,0.00006391988,0.0003026469,0.0004962257,0.0001402134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009996983,"about_ca_system_score_gemma":0.0003376188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009165435,"about_ca_topic_score_gemma":0.0007418292,"domain_scores_codex":[0.9962908,0.001816511,0.0002788027,0.0004881975,0.0007586384,0.0003670541],"domain_scores_gemma":[0.9986055,0.0007111226,0.00003978928,0.000334788,0.0001052901,0.0002034427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02374545,0.0031471,0.9343521,0.00003003335,0.002541756,0.003873834,0.005531281,0.0002444144,0.01951806,0.0006669961,0.000675499,0.005673449],"study_design_scores_gemma":[0.006271441,0.002349681,0.9854109,0.000006930374,0.0002627298,0.0000334519,0.0009422131,0.001297132,0.000191003,0.001362837,0.001764057,0.0001076542],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959531,0.000648235,0.00003109843,0.002110182,0.00006031771,0.0006694072,0.0000653837,0.00001793414,0.0004443321],"genre_scores_gemma":[0.9972186,0.00001220189,0.0005342523,0.0001004771,0.00002886959,0.000295393,0.0003258545,0.0000175365,0.00146678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05105874,"threshold_uncertainty_score":0.9998082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04636021055271448,"score_gpt":0.3625567493310642,"score_spread":0.3161965387783497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}