{"id":"W4283259569","doi":"10.1038/s41379-022-01104-9","title":"Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study","year":2022,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; University of Alberta; Ontario Institute for Cancer Research; McMaster University; Juravinski Hospital; University of British Columbia","funders":"National Center for Advancing Translational Sciences","keywords":"Biopsy; Medicine; Breast cancer; Core biopsy; Immunohistochemistry; Pathology; Radiology; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002684896,0.0001775523,0.000265418,0.000147368,0.0002227938,0.00002839193,0.0001562636,0.00006779605,0.00003685491],"category_scores_gemma":[0.00005767472,0.0001708942,0.00003465431,0.0001167961,0.00006537979,0.000003122635,0.0003205023,0.0001391362,0.000004046517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001593265,"about_ca_system_score_gemma":0.0001129189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003639324,"about_ca_topic_score_gemma":0.001419123,"domain_scores_codex":[0.9986401,0.000155134,0.0002773509,0.000544154,0.0001389724,0.0002443494],"domain_scores_gemma":[0.9994801,0.00004095808,0.0000659713,0.0002663872,0.00005620605,0.00009038653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002693873,0.001530787,0.3993134,0.00006775989,0.00008730721,0.0003431142,0.001439191,0.04840664,0.5440943,0.0004760253,0.0005177429,0.00102984],"study_design_scores_gemma":[0.007412278,0.001812368,0.9661376,0.0001039465,0.00005440254,0.0005128308,0.001087388,0.01873284,0.002100546,0.00005983805,0.001308762,0.0006772354],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995461,0.0003926478,0.002041347,0.0002004197,0.0005072512,0.0006922731,0.0006694387,0.00001149486,0.0000240622],"genre_scores_gemma":[0.9977285,0.00003038952,0.001041474,0.0004059905,0.0001223992,0.0004338632,0.00008676262,0.00002237494,0.000128302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5668241,"threshold_uncertainty_score":0.6968863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04746922533072951,"score_gpt":0.3070318646097429,"score_spread":0.2595626392790134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}