{"id":"W4283261057","doi":"10.1016/j.biopsych.2022.06.012","title":"Associations of DNA Methylation With Behavioral Problems, Gray Matter Volumes, and Negative Life Events Across Adolescence: Evidence From the Longitudinal IMAGEN Study","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Medical Research Foundation; National Institute on Drug Abuse; National Key Research and Development Program of China; Horizon 2020; Medical Research Council; Higher Education Discipline Innovation Project; Université Paris-Sud; Shire; Fédération pour la Recherche sur le Cerveau; Science and Technology Commission of Shanghai Municipality; Fondation pour la Recherche Médicale; National Natural Science Foundation of China; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; UK Research and Innovation; Science Foundation Ireland; Assistance Publique - Hôpitaux de Paris; European Commission; Fondation de France; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Deutsche Forschungsgemeinschaft; King's College London; South London and Maudsley NHS Foundation Trust; King’s College London; National Institutes of Health; Fondation de l'Avenir pour la Recherche Médicale Appliquée","keywords":"DNA methylation; Epigenetics; Psychology; Longitudinal study; Methylation; Psychopathology; Epigenome; Clinical psychology; Biology; Genetics; Gene; Medicine; Gene expression; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001069362,0.0003437832,0.0003842494,0.0008654089,0.0007488239,0.0007465364,0.0006146776,0.0008153364,0.001120084],"category_scores_gemma":[0.002884546,0.0004540659,0.000540943,0.001111456,0.0004957556,0.000488106,0.0007913434,0.0009316599,0.0001045145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004004286,"about_ca_system_score_gemma":0.000444056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02903466,"about_ca_topic_score_gemma":0.04372897,"domain_scores_codex":[0.9994882,0.0001608271,0.00003302642,0.0001656406,0.00007074628,0.00008145907],"domain_scores_gemma":[0.9979995,0.0003504174,0.0008057295,0.000193342,0.0002829983,0.0003680438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001540231,0.00005675391,0.9976433,0.000008046707,0.0001731348,0.00003632038,0.0001378411,0.00002145248,0.0003386566,0.00003892682,0.00008692731,0.001304616],"study_design_scores_gemma":[0.000003675898,0.00002790313,0.999589,0.000004277591,0.00004686471,0.0000390774,0.00008487414,0.00003293171,0.00004104679,0.00002421761,0.000104107,0.000001951975],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979377,0.0007656602,0.00009503887,0.0001542879,0.000009646884,0.000005646319,0.0005406946,0.000003510057,0.0004878245],"genre_scores_gemma":[0.9980832,0.0005991475,0.0001739896,0.00006009732,0.0000105314,0.00001308411,0.0005321254,0.000004554727,0.0005231052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02903466,"threshold_uncertainty_score":0.05773127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1130813754195469,"score_gpt":0.3802968840788913,"score_spread":0.2672155086593444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}