{"id":"W4283261057","doi":"10.1016/j.biopsych.2022.06.012","title":"Associations of DNA Methylation With Behavioral Problems, Gray Matter Volumes, and Negative Life Events Across Adolescence: Evidence From the Longitudinal IMAGEN Study","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Medical Research Foundation; National Institute on Drug Abuse; National Key Research and Development Program of China; Horizon 2020; Medical Research Council; Higher Education Discipline Innovation Project; Université Paris-Sud; Shire; Fédération pour la Recherche sur le Cerveau; Science and Technology Commission of Shanghai Municipality; Fondation pour la Recherche Médicale; National Natural Science Foundation of China; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; UK Research and Innovation; Science Foundation Ireland; Assistance Publique - Hôpitaux de Paris; European Commission; Fondation de France; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Deutsche Forschungsgemeinschaft; King's College London; South London and Maudsley NHS Foundation Trust; King’s College London; National Institutes of Health; Fondation de l'Avenir pour la Recherche Médicale Appliquée","keywords":"DNA methylation; Epigenetics; Psychology; Longitudinal study; Methylation; Psychopathology; Epigenome; Clinical psychology; Biology; Genetics; Gene; Medicine; Gene expression; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004541941,0.0001509277,0.0002994821,0.00002402586,0.0003708274,0.00001748002,0.0001373211,0.00006167965,0.0004038691],"category_scores_gemma":[0.0001460731,0.0000908612,0.00007269704,0.0002740154,0.0001285086,0.000120073,0.0001678715,0.0003747583,0.00001154933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005241256,"about_ca_system_score_gemma":0.00008710718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005310881,"about_ca_topic_score_gemma":0.0002541087,"domain_scores_codex":[0.9983041,0.0004273858,0.0003149918,0.00038205,0.0003838031,0.000187718],"domain_scores_gemma":[0.9990824,0.0001954362,0.0003024768,0.0002443347,0.0001101573,0.00006518335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002300204,0.001465782,0.9959946,0.000007691428,0.0001002346,0.000001309275,0.001095274,0.00001468134,0.0005211765,0.000003774089,0.0003867692,0.0001786813],"study_design_scores_gemma":[0.001129876,0.001116812,0.9870546,0.00004693044,0.0001675226,0.000005234992,0.01021325,0.00001729016,0.00000343305,0.00012025,0.00001265566,0.0001121731],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945139,0.0006989665,0.0001654541,0.003100996,0.0001467731,0.001101458,0.0002349286,0.00002797467,0.000009532168],"genre_scores_gemma":[0.9988127,0.00001236072,0.0005376348,0.0003247308,0.00006475122,0.0001182401,0.00007134894,0.00001137129,0.0000469003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009117976,"threshold_uncertainty_score":0.4422084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1130813754195469,"score_gpt":0.3802968840788913,"score_spread":0.2672155086593444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}