{"id":"W4283264832","doi":"10.1038/s41385-022-00539-2","title":"Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota","year":2022,"lang":"en","type":"review","venue":"Mucosal Immunology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada","keywords":"Immune system; Dysbiosis; Immunology; Biology; Systemic inflammation; Immunity; Gut flora; Sepsis; Inflammation; Mucosal immunology; Innate immune system; Commensalism; Acquired immune system; Microbiome; Gastrointestinal tract; Bioinformatics; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005142321,0.0008375356,0.001085137,0.001522832,0.0002565697,0.001187903,0.0008294299,0.001224846,0.004490288],"category_scores_gemma":[0.0006996592,0.0002252915,0.0003994324,0.001346855,0.0004364848,0.001245487,0.0008682197,0.00195397,0.002906152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006328,"about_ca_system_score_gemma":0.001121311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006083974,"about_ca_topic_score_gemma":0.001098281,"domain_scores_codex":[0.9998394,0.00002838318,0.00002006043,0.00002660542,0.00006477704,0.00002081479],"domain_scores_gemma":[0.9997222,0.0001065648,0.00003982532,0.000009499463,0.00007631633,0.00004569908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009061244,0.00005412089,0.0001636249,0.0142221,0.00008554602,0.000188903,0.00004491608,0.0003159402,0.002848597,0.005708654,0.03426144,0.9420156],"study_design_scores_gemma":[0.00001109955,0.00006801028,0.0005908071,0.002368872,0.00005569078,0.0007212685,0.00003430339,0.00005711779,0.0004531028,0.001737049,0.9938899,0.00001258303],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001006705,0.9979326,0.0001486787,0.0003359797,0.0003864996,0.000003975158,0.00001882,0.000008433639,0.001064409],"genre_scores_gemma":[0.0005423979,0.9982046,0.0001528661,0.0001843975,0.0002035023,0.000004941057,0.00002901491,0.000001693462,0.0006764912],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004490288,"threshold_uncertainty_score":0.0150215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02945437598533491,"score_gpt":0.2836025592046778,"score_spread":0.2541481832193429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}