{"id":"W4283270985","doi":"10.1126/scitranslmed.abn3353","title":"B cell targeting in CAR T cell therapy: Side effect or driver of CAR T cell function?","year":2022,"lang":"en","type":"review","venue":"Science Translational Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Chimeric antigen receptor; CD19; CAR T-cell therapy; T cell; Cell; B cell; Cancer research; Cell therapy; Medicine; Antigen; Immunology; Biology; Immune system; Antibody; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004802345,0.000607784,0.002245581,0.00163419,0.000257578,0.00001648668,0.0007438498,0.00020068,0.01812988],"category_scores_gemma":[0.0002089066,0.0003988493,0.0004525323,0.004172915,0.001240865,0.0001757844,0.00007100977,0.001415794,0.00003757716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004258011,"about_ca_system_score_gemma":0.003274735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002379515,"about_ca_topic_score_gemma":0.00001178022,"domain_scores_codex":[0.9929256,0.000546038,0.001295505,0.001091565,0.003352984,0.0007883027],"domain_scores_gemma":[0.9961549,0.002165803,0.0004277425,0.0006506126,0.0002327579,0.0003681919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00172991,0.0008079444,0.001084771,0.03225431,0.0001476777,0.0003337937,0.003262746,0.0001936694,0.06882177,0.00004100243,0.001760021,0.8895624],"study_design_scores_gemma":[0.00518383,0.002726933,0.000212327,0.00302005,0.0004823888,0.00004192527,0.0002432476,0.0001260064,0.001451783,0.00003488996,0.9860386,0.0004380775],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002138645,0.9780902,0.00004928783,0.0002285588,0.0007446026,0.003008045,0.00004534486,0.0000446883,0.0156506],"genre_scores_gemma":[0.008971919,0.9843902,0.0002347657,0.0001452261,0.0005736311,0.0002272478,0.0002884266,0.0001027225,0.005065882],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9842785,"threshold_uncertainty_score":0.9998463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06806536564021057,"score_gpt":0.3772436598798643,"score_spread":0.3091782942396537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}