{"id":"W4283270985","doi":"10.1126/scitranslmed.abn3353","title":"B cell targeting in CAR T cell therapy: Side effect or driver of CAR T cell function?","year":2022,"lang":"en","type":"review","venue":"Science Translational Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Chimeric antigen receptor; CD19; CAR T-cell therapy; T cell; Cell; B cell; Cancer research; Cell therapy; Medicine; Antigen; Immunology; Biology; Immune system; Antibody; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001423639,0.0007766259,0.001782973,0.001326337,0.0002518683,0.001170187,0.00139671,0.002039889,0.003544441],"category_scores_gemma":[0.0009983544,0.0003485617,0.0005800757,0.001240902,0.001007712,0.002174621,0.0006912648,0.003813378,0.00246603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007667756,"about_ca_system_score_gemma":0.0008915165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009544016,"about_ca_topic_score_gemma":0.001761449,"domain_scores_codex":[0.9997354,0.00007898177,0.00002772976,0.00003983185,0.00008695845,0.00003101099],"domain_scores_gemma":[0.9995663,0.0002526568,0.00004114168,0.00001563094,0.00008965198,0.00003471217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001270725,0.00008442738,0.00009870947,0.01375745,0.00008544882,0.0002571919,0.00006693849,0.0005226643,0.002809076,0.01216679,0.04163618,0.9283879],"study_design_scores_gemma":[0.00004600015,0.0001456917,0.0002285252,0.003652802,0.00008502922,0.001261409,0.0000456169,0.0001026401,0.0006649443,0.003896813,0.9898506,0.00001972317],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007802568,0.9982285,0.0001697381,0.0006339549,0.0002600921,0.000003368924,0.000008841312,0.000005970362,0.000611498],"genre_scores_gemma":[0.0005839403,0.997788,0.0002020945,0.000619828,0.0002509831,0.000008228931,0.00001584833,0.00000245853,0.0005286264],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003544441,"threshold_uncertainty_score":0.01185739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06806536564021057,"score_gpt":0.3772436598798643,"score_spread":0.3091782942396537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}