{"id":"W4283271852","doi":"10.1016/j.etap.2022.103915","title":"Cylindrospermopsin induces oocyte maturation and disrupts gene expression in zebrafish ovarian follicles","year":2022,"lang":"en","type":"article","venue":"Environmental Toxicology and Pharmacology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Zebrafish; Oocyte; Biology; Germinal vesicle; Testosterone (patch); Ovarian follicle; Follicle; Gene expression; Andrology; Cell biology; Internal medicine; Gonadotropin; Cylindrospermopsin; Endocrinology; Gene; Ovary; Genetics; Medicine; Hormone; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145012,0.0003053804,0.00020524,0.0004833109,0.0002447414,0.0002405364,0.0002426755,0.000497231,0.001566549],"category_scores_gemma":[0.0001719041,0.0003143318,0.0004000438,0.0001615433,0.0004998192,0.0002324114,0.0002916621,0.0007469523,0.0002610305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001037081,"about_ca_system_score_gemma":0.0006579414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007361483,"about_ca_topic_score_gemma":0.01703711,"domain_scores_codex":[0.9997498,0.0000196259,0.00001799495,0.00005522985,0.00008326695,0.00007402018],"domain_scores_gemma":[0.9997626,0.00003706144,0.00008344107,0.00002351988,0.00002433026,0.00006911553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000471916,0.000005046075,0.0001287556,0.000006868725,0.000001331258,0.00004064389,0.00001082453,0.00002931554,0.9995143,0.000065579,0.00001433028,0.0001357533],"study_design_scores_gemma":[0.0000216913,0.0001540166,0.01257509,0.000005403019,0.00001256947,0.0001534025,0.00007993636,0.0005273039,0.9851472,0.00005130565,0.001263027,0.000009082729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951799,0.00040396,0.001597145,0.0001835242,0.00004068511,0.00003366735,0.0004928525,0.00007512884,0.001993184],"genre_scores_gemma":[0.9898714,0.0003121669,0.0012176,0.0001315783,0.000007764043,0.00003409387,0.0003864775,0.00004157746,0.007997178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007361483,"threshold_uncertainty_score":0.01463723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577556767990722,"score_gpt":0.2786084465379985,"score_spread":0.2628328788580913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}