{"id":"W4283273802","doi":"10.1021/acs.biochem.2c00197","title":"Sequence Divergence in the Arginase Domain of Ornithine Decarboxylase/Arginase in <i>Fusobacteriacea</i> Leads to Loss of Function in Oral Associated Species","year":2022,"lang":"en","type":"article","venue":"Biochemistry","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Arginase; Ornithine; Biochemistry; Arginine; Ornithine decarboxylase; Amino acid; Biology; Ornithine decarboxylase antizyme; Asparagine; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000190672,0.0004020586,0.0003207985,0.0001925327,0.0001635283,0.0004047204,0.0002593545,0.000367588,0.0006943581],"category_scores_gemma":[0.0003128588,0.0001410009,0.0004489883,0.0002667094,0.000235156,0.0001693169,0.0003473773,0.0006580948,0.0005130918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004095765,"about_ca_system_score_gemma":0.0002663014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002180568,"about_ca_topic_score_gemma":0.001923097,"domain_scores_codex":[0.9998068,0.00002920211,0.00002913146,0.00003527032,0.00005201958,0.00004769244],"domain_scores_gemma":[0.9997935,0.00003336446,0.00006527717,0.00002584101,0.00002109971,0.0000608781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093224,0.00002085545,0.0005262755,0.00001921369,0.000009352947,0.0002240844,0.0000231374,0.00006064546,0.9977401,0.00005834993,0.00003879107,0.001169901],"study_design_scores_gemma":[0.00003932078,0.0003656399,0.03998723,0.00003476694,0.00007737378,0.003498448,0.0003338945,0.002342316,0.9451033,0.0001508146,0.008034917,0.00003181286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956464,0.0003208528,0.002694648,0.00008515011,0.00003835016,0.00002164853,0.0004695528,0.00007445981,0.000648999],"genre_scores_gemma":[0.9965746,0.0001335138,0.001534849,0.00008077543,0.000007984621,0.00001209901,0.0009444934,0.00003769124,0.0006739991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002180568,"threshold_uncertainty_score":0.004335761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179447478163009,"score_gpt":0.2366967537541306,"score_spread":0.2249022789725005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}