{"id":"W4283274833","doi":"10.1111/age.13214","title":"The c.612A>G mutation of MC4R affects constitutive activity and signaling in domestic goats","year":2022,"lang":"en","type":"article","venue":"Animal Genetics","topic":"Reproductive Physiology in Livestock","field":"Agricultural and Biological Sciences","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"","keywords":"Biology; Allele; Receptor; Signal transduction; Mutant; G protein-coupled receptor; Gene; Mutation; Coding region; Stimulation; Genetics; Wild type; Internal medicine; Molecular biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690128,0.00009382217,0.0001320989,0.000009932844,0.000297528,0.00001533548,0.0001490908,0.00003325408,0.000005306629],"category_scores_gemma":[0.0001862532,0.00004087501,0.00003063976,0.0002551499,0.0003037551,0.00004215,0.000169201,0.0001496604,0.000001452515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002260737,"about_ca_system_score_gemma":0.00001662544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004630972,"about_ca_topic_score_gemma":0.00003845614,"domain_scores_codex":[0.9990461,0.0002435227,0.0001158385,0.0002657791,0.0001454121,0.0001833699],"domain_scores_gemma":[0.9987068,0.001049706,0.0001185714,0.00005378871,0.00003974504,0.00003136907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002466061,0.00005325848,0.009127246,0.000004052079,0.00001021156,0.000006583535,0.0002056727,0.0007039345,0.9859475,0.0004471892,0.0000342636,0.003435399],"study_design_scores_gemma":[0.0001282675,0.001891707,0.9394761,0.000006014075,0.00001399345,0.00003038655,0.0008030768,0.0001987225,0.05453479,0.002393772,0.0004704433,0.00005277095],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984107,0.0008143686,0.000002065388,0.0001254848,0.00007777938,0.000273992,0.00002018735,0.00001118558,0.0002642621],"genre_scores_gemma":[0.9997175,0.00006420122,0.00005464929,0.00003444129,0.00006342753,0.00003280824,0.000005264577,8.992672e-7,0.00002680564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9314128,"threshold_uncertainty_score":0.2288375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669885170265336,"score_gpt":0.2387685895126901,"score_spread":0.2220697378100367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}