{"id":"W4283274833","doi":"10.1111/age.13214","title":"The c.612A>G mutation of MC4R affects constitutive activity and signaling in domestic goats","year":2022,"lang":"en","type":"article","venue":"Animal Genetics","topic":"Reproductive Physiology in Livestock","field":"Agricultural and Biological Sciences","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"","keywords":"Biology; Allele; Receptor; Signal transduction; Mutant; G protein-coupled receptor; Gene; Mutation; Coding region; Stimulation; Genetics; Wild type; Internal medicine; Molecular biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003125988,0.0007489345,0.0003735753,0.0006636686,0.0003780752,0.0003382374,0.000555356,0.0009510525,0.004521064],"category_scores_gemma":[0.0003604525,0.0003055644,0.0009509931,0.0002759116,0.0009905196,0.0001753833,0.0003850589,0.0008685941,0.001360949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003923371,"about_ca_system_score_gemma":0.0002486266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001816249,"about_ca_topic_score_gemma":0.001287516,"domain_scores_codex":[0.9995746,0.000112805,0.00006104795,0.000105209,0.0000688728,0.00007755764],"domain_scores_gemma":[0.9995978,0.0000922145,0.000139381,0.00003643224,0.00001931977,0.0001147531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005766095,0.0001535402,0.001394827,0.00005180432,0.00006796871,0.003688726,0.0001172948,0.0002012101,0.9915475,0.0003778942,0.0002336885,0.001588863],"study_design_scores_gemma":[0.0009517331,0.003831185,0.1265247,0.0001220311,0.0005210034,0.04616217,0.0006916925,0.008418334,0.7901562,0.0008178707,0.02160344,0.0001997322],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955351,0.0002822629,0.001678718,0.0002678599,0.000113362,0.00007683411,0.0005599161,0.00007894399,0.001406998],"genre_scores_gemma":[0.994419,0.0001932075,0.001277712,0.0002513766,0.0001038081,0.00009200283,0.0006877615,0.0001587053,0.002816545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004521064,"threshold_uncertainty_score":0.0151245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669885170265336,"score_gpt":0.2387685895126901,"score_spread":0.2220697378100367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}