{"id":"W4283275189","doi":"10.1021/acs.jmedchem.2c00359","title":"Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4","year":2022,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Ministère de l'Économie, de la Science et de l'Innovation - Québec","keywords":"Chemistry; Pharmacology; Antithrombotic; Clopidogrel; Platelet; Thrombin; Coagulation; Discovery and development of direct thrombin inhibitors; Receptor; Thrombosis; Platelet activation; Aspirin; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002835669,0.0005275131,0.0006057973,0.0004554815,0.000204622,0.0004493345,0.0003952459,0.0004523467,0.002216449],"category_scores_gemma":[0.0003216993,0.0001752467,0.0003426297,0.0002986547,0.0002271592,0.0002720187,0.0002251152,0.0009655548,0.0004139166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000247177,"about_ca_system_score_gemma":0.0006559154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003001993,"about_ca_topic_score_gemma":0.001131323,"domain_scores_codex":[0.9998753,0.00001707339,0.00001182355,0.0000204937,0.0000383294,0.00003690668],"domain_scores_gemma":[0.9999129,0.000007168739,0.00001735744,0.00000619426,0.00001776759,0.00003866221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002364568,0.001870522,0.001608807,0.0003555199,0.0001092582,0.0009305314,0.00010223,0.001874381,0.8848888,0.002226105,0.002971907,0.1006973],"study_design_scores_gemma":[0.01252019,0.07185508,0.01907614,0.0001293221,0.0008614348,0.007178802,0.0001538812,0.008541647,0.784766,0.001327901,0.09344774,0.0001419447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736138,0.008781773,0.005766044,0.00127739,0.0002869275,0.0008620294,0.001237328,0.0001961479,0.007978559],"genre_scores_gemma":[0.9704111,0.009078735,0.01217491,0.0009699403,0.0001473235,0.0003223325,0.002320238,0.00002305794,0.004552291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002216449,"threshold_uncertainty_score":0.007414818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02639156044833222,"score_gpt":0.3063316368296957,"score_spread":0.2799400763813634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}