{"id":"W4283277479","doi":"10.1021/jacs.2c00521","title":"The Biosynthetic Landscape of Triceptides Reveals Radical SAM Enzymes That Catalyze Cyclophane Formation on Tyr- and His-Containing Motifs","year":2022,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Science Education Institute, Department of Science and Technology, Republic of the Philippines; Human Frontier Science Program; Department of Science and Technology, Republic of the Philippines; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Ministry of Education - Singapore; Naito Foundation","keywords":"Cyclophane; Chemistry; Stereochemistry; Amino acid; Enzyme; Aromatic amino acids; Peptide; Biosynthesis; Combinatorial chemistry; Biochemistry; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006266662,0.0001895959,0.0001312632,0.0002970766,0.00008336318,0.0002011309,0.00009573527,0.0001459021,0.0004413604],"category_scores_gemma":[0.0001064177,0.00009199941,0.0002073518,0.0002335909,0.0001005913,0.000178981,0.0001263381,0.0002165593,0.0001610395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001233283,"about_ca_system_score_gemma":0.00009456373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002801389,"about_ca_topic_score_gemma":0.0003414926,"domain_scores_codex":[0.9999607,0.000003867606,0.000002582176,0.00001629327,0.000007535536,0.000009099617],"domain_scores_gemma":[0.9999316,0.00001299598,0.0000276456,0.000005718217,0.000007012871,0.00001505059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001107654,0.00001119124,0.003410051,0.00003529012,0.000006791547,0.0001461746,0.00003203179,0.0002938473,0.9906163,0.0001201766,0.00002624418,0.005191113],"study_design_scores_gemma":[0.00001348004,0.0005146431,0.1218581,0.00002197039,0.00006913345,0.002179186,0.0002746638,0.01272011,0.8569734,0.0006361306,0.004716642,0.00002251737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957995,0.0003639323,0.002858259,0.00002870608,0.00000197062,0.000008113378,0.0003449118,0.00004532448,0.0005492761],"genre_scores_gemma":[0.9913543,0.0004164382,0.006457925,0.00002218436,0.000003125024,0.00001022692,0.001180869,0.00002171382,0.0005331674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004413604,"threshold_uncertainty_score":0.001476526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007405588514358788,"score_gpt":0.2248905045634721,"score_spread":0.2174849160491133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}