{"id":"W4283311401","doi":"10.3389/fnins.2022.917197","title":"Metabolomics: The Key to Unraveling the Role of the Microbiome in Visceral Pain Neurotransmission","year":2022,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; W. Garfield Weston Foundation; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Irritable bowel syndrome; Medicine; Abdominal pain; Visceral pain; Microbiome; Metabolome; Inflammatory bowel disease; Dysbiosis; Gastrointestinal tract; Disease; Ulcerative colitis; Inflammation; Chronic pain; Immunology; Gut flora; Gastroenterology; Internal medicine; Bioinformatics; Nociception; Metabolite; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001360173,0.00102037,0.001848758,0.002082504,0.0004759934,0.00307034,0.0007249605,0.002145286,0.003619819],"category_scores_gemma":[0.002026345,0.0003835827,0.001038455,0.002090075,0.0009697977,0.003239392,0.001456245,0.003087912,0.001893192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008708896,"about_ca_system_score_gemma":0.001551478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00136559,"about_ca_topic_score_gemma":0.001669983,"domain_scores_codex":[0.9992782,0.0001665204,0.00005010135,0.0001571523,0.0002743774,0.00007363872],"domain_scores_gemma":[0.9988737,0.0004050974,0.0001606706,0.00006954572,0.00038298,0.0001081153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004553977,0.0001649506,0.006999612,0.01718959,0.0008071454,0.001138412,0.0004853318,0.001523916,0.1382572,0.0217718,0.0463312,0.7648755],"study_design_scores_gemma":[0.00004455433,0.0004570821,0.01283552,0.003780317,0.0005338953,0.003049374,0.0008433437,0.0031787,0.04409809,0.0305714,0.9003289,0.000278754],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008295462,0.9455222,0.02392202,0.01013532,0.002402539,0.00007123894,0.001677884,0.0004766812,0.007496628],"genre_scores_gemma":[0.04006039,0.9217396,0.02521488,0.004317375,0.003124231,0.00007841404,0.001321537,0.0001194316,0.004023987],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003619819,"threshold_uncertainty_score":0.01210952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911543228321994,"score_gpt":0.2783840962470993,"score_spread":0.2592686639638794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}