{"id":"W4283311401","doi":"10.3389/fnins.2022.917197","title":"Metabolomics: The Key to Unraveling the Role of the Microbiome in Visceral Pain Neurotransmission","year":2022,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; W. Garfield Weston Foundation; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Irritable bowel syndrome; Medicine; Abdominal pain; Visceral pain; Microbiome; Metabolome; Inflammatory bowel disease; Dysbiosis; Gastrointestinal tract; Disease; Ulcerative colitis; Inflammation; Chronic pain; Immunology; Gut flora; Gastroenterology; Internal medicine; Bioinformatics; Nociception; Metabolite; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001519625,0.0002539732,0.0004787484,0.0001324852,0.0002476235,0.00003337026,0.001950314,0.0001226002,0.000004265258],"category_scores_gemma":[0.0002501901,0.0001310836,0.0002472412,0.0009900187,0.0002391559,0.000003537437,0.0005202134,0.0005681472,5.476771e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004807502,"about_ca_system_score_gemma":0.0004108537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005311844,"about_ca_topic_score_gemma":0.00002522148,"domain_scores_codex":[0.9971403,0.001189001,0.0004958433,0.0005942937,0.0001736347,0.0004069143],"domain_scores_gemma":[0.9989301,0.00004792649,0.0002194421,0.0007393685,0.00001284201,0.00005031301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004268557,0.0001360946,0.0005523991,0.001099381,0.00001222399,0.000005532646,0.000727469,0.0003579122,0.2504884,0.00004813325,0.005249267,0.7412806],"study_design_scores_gemma":[0.00007122876,0.00006213276,0.0002149974,0.0002676144,0.00002138181,0.00001466911,0.00008206344,0.00007545267,0.0005980938,0.00001784763,0.9984348,0.0001397508],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001661587,0.9942387,0.0003852268,0.0004699587,0.001693792,0.001400876,0.00006590055,0.000004157192,0.00007979068],"genre_scores_gemma":[0.001377472,0.9959758,0.0002601092,0.001962345,0.00005842152,0.00008568574,0.00001182827,0.00003348535,0.0002348881],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9931855,"threshold_uncertainty_score":0.5345433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911543228321994,"score_gpt":0.2783840962470993,"score_spread":0.2592686639638794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}