{"id":"W4283315834","doi":"10.1111/eva.13441","title":"Co‐evolutionary adaptations of <i>Acinetobacter baumannii</i> and a clinical carbapenemase‐encoding plasmid during carbapenem exposure","year":2022,"lang":"en","type":"article","venue":"Evolutionary Applications","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Natural Science Foundation of China","keywords":"Acinetobacter baumannii; Biology; Plasmid; Experimental evolution; Genetics; Imipenem; Carbapenem; Evolutionary dynamics; Phenotype; Gene duplication; Genotype; Population; Microbiology; Gene; Antibiotic resistance; Antibiotics; Bacteria; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793552,0.0002946873,0.0002861671,0.0002524367,0.0001824642,0.0004575217,0.0002395368,0.0002900054,0.0006474387],"category_scores_gemma":[0.0004579491,0.000156169,0.0002335394,0.0002733964,0.000173237,0.0002290367,0.0003922524,0.0004015735,0.0002119512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003515817,"about_ca_system_score_gemma":0.0002408116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001281394,"about_ca_topic_score_gemma":0.001139995,"domain_scores_codex":[0.9996953,0.00005158145,0.0000232953,0.00007708134,0.00008023726,0.00007264999],"domain_scores_gemma":[0.9997286,0.00005690612,0.00008009605,0.00003519545,0.0000469141,0.00005221541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001227277,0.00005059384,0.004561663,0.00001246316,0.00001021402,0.00006521076,0.00003628051,0.0001478361,0.9934243,0.00004285208,0.0000226852,0.001503228],"study_design_scores_gemma":[0.00002332562,0.0016122,0.3019721,0.00001371815,0.00006788378,0.002261779,0.0006311903,0.005260218,0.6857573,0.0001310775,0.002230271,0.0000390676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992964,0.00005731081,0.0002764015,0.0000179656,0.000002696009,0.000008004474,0.0000839343,0.00001234858,0.000244746],"genre_scores_gemma":[0.998552,0.0000479772,0.0006474542,0.00002017941,0.000002474345,0.00001303865,0.0003004469,0.00001333246,0.000403117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281394,"threshold_uncertainty_score":0.0025509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227251880281555,"score_gpt":0.2705699860233332,"score_spread":0.2582974672205176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}