{"id":"W4283316269","doi":"10.1002/jcb.30301","title":"Induction of endoplasmic reticulum stress markers in an acromegaly model","year":2022,"lang":"en","type":"article","venue":"Journal of Cellular Biochemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint Paul University","funders":"","keywords":"Acromegaly; Unfolded protein response; XBP1; Endoplasmic reticulum; Somatic cell; RNA splicing; Internal medicine; Endocrinology; Medicine; Biology; Hormone; Cell biology; Gene; Genetics; Growth hormone; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003469551,0.0001702368,0.0002549221,0.0001023357,0.00006212894,0.00001553583,0.0003872428,0.0001187412,0.00005776261],"category_scores_gemma":[0.00007597977,0.0001757772,0.0001993461,0.0001439066,0.00009412928,0.00001213643,0.000157501,0.0003116098,2.633387e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000497017,"about_ca_system_score_gemma":0.0002996226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009005329,"about_ca_topic_score_gemma":0.000003009907,"domain_scores_codex":[0.9984577,0.00009758463,0.0005832459,0.0002546534,0.0003821662,0.0002246461],"domain_scores_gemma":[0.998813,0.000008843954,0.0005171908,0.0003553097,0.0001440459,0.0001616244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004864435,0.0003778503,0.004635065,0.00007701148,0.00004324326,0.00005554314,0.00005284038,0.01659361,0.9771408,0.000008876116,0.0003315442,0.0001971638],"study_design_scores_gemma":[0.001156952,0.0003825866,0.0002476921,0.00003317899,0.00003936694,0.0001078602,0.0009391326,0.001955591,0.9947925,0.00006657311,0.00009841524,0.0001801932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978165,0.001092406,0.0003361754,0.00004478372,0.0001534112,0.00007503256,0.00009394926,0.000002829299,0.0003848897],"genre_scores_gemma":[0.9988708,0.0001133962,0.0005035846,0.00003195872,0.0001277944,0.000008576407,0.0001178861,0.00002338193,0.0002026192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01765165,"threshold_uncertainty_score":0.7167985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006724875860658067,"score_gpt":0.2299915704447245,"score_spread":0.2232666945840665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}