{"id":"W4283319121","doi":"10.1136/jitc-2021-004458","title":"Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Medical Research Council; National Cancer Institute; National Research, Development and Innovation Office; Radiumhemmets Forskningsfonder; Cancerföreningen i Stockholm; Vetenskapsrådet; Karolinska Institutet; Cancerfonden; Knut och Alice Wallenbergs Stiftelse; Kommunfullmäktige, Stockholms Stad; Stiftelsen Tornspiran","keywords":"Auranofin; Cytotoxic T cell; Oxidative stress; Degranulation; Chemistry; Cancer research; CD19; Reactive oxygen species; Flow cytometry; Immunology; Pharmacology; Cell biology; Biology; In vitro; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213265,0.0001531712,0.0002640283,0.00005312999,0.0002856237,0.00001830384,0.0002231842,0.00005131107,0.00004533966],"category_scores_gemma":[0.0000121549,0.0001508362,0.0001318953,0.00004185549,0.0001389843,0.00000913305,0.00008375834,0.0001551083,4.251931e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003816026,"about_ca_system_score_gemma":0.00008157772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005217636,"about_ca_topic_score_gemma":0.000005162,"domain_scores_codex":[0.9989741,0.00007972156,0.000379063,0.000207233,0.0001445827,0.000215309],"domain_scores_gemma":[0.9991489,0.00002091206,0.0005001379,0.0001421008,0.0001436025,0.00004432176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001180129,0.00007866339,0.001114049,0.00007291511,0.0001774737,6.533284e-7,0.0003674306,0.000144494,0.9953559,0.000003301753,0.0009459871,0.0005590063],"study_design_scores_gemma":[0.001457325,0.0005459422,0.0007197998,0.00002830249,0.00001891321,0.000003622902,0.0007092757,0.00000670463,0.9872785,0.00004882318,0.009017917,0.0001648556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799948,0.01822764,0.00008810563,0.00003652692,0.0002569994,0.0001977088,0.00118194,0.000002426064,0.00001382092],"genre_scores_gemma":[0.994281,0.00425111,0.0004112048,0.00005069859,0.0001606862,0.0000314983,0.00004835846,0.00003325353,0.0007322129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01428614,"threshold_uncertainty_score":0.6150922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007982904849460928,"score_gpt":0.2779203625517257,"score_spread":0.2699374577022648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}