{"id":"W4283319121","doi":"10.1136/jitc-2021-004458","title":"Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Medical Research Council; National Cancer Institute; National Research, Development and Innovation Office; Radiumhemmets Forskningsfonder; Cancerföreningen i Stockholm; Vetenskapsrådet; Karolinska Institutet; Cancerfonden; Knut och Alice Wallenbergs Stiftelse; Kommunfullmäktige, Stockholms Stad; Stiftelsen Tornspiran","keywords":"Auranofin; Cytotoxic T cell; Oxidative stress; Degranulation; Chemistry; Cancer research; CD19; Reactive oxygen species; Flow cytometry; Immunology; Pharmacology; Cell biology; Biology; In vitro; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007602081,0.0002107829,0.0002210498,0.00007920637,0.00007677593,0.0001643515,0.00009405662,0.0001664286,0.002033308],"category_scores_gemma":[0.00007805265,0.00004414206,0.0001582882,0.00005319598,0.0001183662,0.000154354,0.0001282609,0.0003062224,0.0004184824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009460649,"about_ca_system_score_gemma":0.0001329797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001288939,"about_ca_topic_score_gemma":0.0002096689,"domain_scores_codex":[0.9999282,0.00001217503,0.000006893446,0.00001965699,0.0000113626,0.00002170654],"domain_scores_gemma":[0.9999642,0.000005094733,0.000009541282,0.000005038347,0.000005507612,0.00001061198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006917404,0.0001543505,0.0002704991,0.00006439117,0.000006559217,0.00004049278,0.00002385206,0.0001251414,0.994185,0.00004103782,0.00009916008,0.00429779],"study_design_scores_gemma":[0.0001068726,0.002387423,0.001843398,0.000007339131,0.00003503244,0.0003454638,0.00003363701,0.0006568274,0.9915618,0.00004191519,0.002976574,0.000003755331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971395,0.0006968992,0.001186567,0.00006389675,0.00002260719,0.0000263737,0.00008832159,0.00004996928,0.0007259253],"genre_scores_gemma":[0.9975647,0.0002586405,0.0006431649,0.00003863843,0.000009280733,0.00003597333,0.0001695848,0.000008241043,0.001271852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002033308,"threshold_uncertainty_score":0.006802022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007982904849460928,"score_gpt":0.2779203625517257,"score_spread":0.2699374577022648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}