{"id":"W4283324819","doi":"10.3389/fnagi.2022.883256","title":"Selective Serotonin Reuptake Inhibitor-Treatment Does Not Show Beneficial Effects on Cognition or Amyloid Burden in Cognitively Impaired and Cognitively Normal Subjects","year":2022,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; Fujirebio US; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; National Institute on Aging; Alzheimer's Association","keywords":"Serotonin reuptake inhibitor; Psychology; Internal medicine; Depression (economics); Cognition; Antidepressant; Medicine; Oncology; Psychiatry; Hippocampus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005583248,0.0002870664,0.0006237633,0.0004371366,0.0002128266,0.0003546716,0.0001515591,0.0003344185,0.0006699386],"category_scores_gemma":[0.001325556,0.0001368732,0.0004957025,0.0002770783,0.0002355736,0.0001899131,0.0001498357,0.0002511509,0.0001499841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002473298,"about_ca_system_score_gemma":0.0001724684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002778991,"about_ca_topic_score_gemma":0.00535598,"domain_scores_codex":[0.9996595,0.0000999259,0.00005114532,0.00005143656,0.00009279053,0.00004516077],"domain_scores_gemma":[0.99896,0.0002608589,0.0004193014,0.00009836187,0.00009271173,0.0001687161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01003536,0.0004708151,0.9566933,0.0001005484,0.00131843,0.0009972841,0.0001370731,0.0001531387,0.01050052,0.00004096534,0.0001600815,0.01939249],"study_design_scores_gemma":[0.00004482556,0.0008783,0.998135,0.000002523861,0.0001114953,0.0003632294,0.00001726769,0.00004620254,0.0002965266,0.00001700979,0.0000859116,0.000001756249],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981761,0.001161208,0.00002669101,0.00001455537,0.000003994097,0.000004790111,0.00006867308,0.00000310802,0.0005408958],"genre_scores_gemma":[0.999426,0.0002424334,0.00002888664,0.00002973725,0.000008926144,0.000002130287,0.000150577,8.953148e-7,0.0001104488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002778991,"threshold_uncertainty_score":0.005525649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728895445562982,"score_gpt":0.2794089545519673,"score_spread":0.2621200000963375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}