{"id":"W4283324819","doi":"10.3389/fnagi.2022.883256","title":"Selective Serotonin Reuptake Inhibitor-Treatment Does Not Show Beneficial Effects on Cognition or Amyloid Burden in Cognitively Impaired and Cognitively Normal Subjects","year":2022,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; Fujirebio US; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; National Institute on Aging; Alzheimer's Association","keywords":"Serotonin reuptake inhibitor; Psychology; Internal medicine; Depression (economics); Cognition; Antidepressant; Medicine; Oncology; Psychiatry; Hippocampus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007123077,0.0003807587,0.0005064899,0.001017,0.0005179783,0.0001098443,0.0001813317,0.00006869443,0.00002842299],"category_scores_gemma":[0.0004635358,0.0003110785,0.00007998725,0.001383076,0.0003257205,0.0003123874,0.0002351292,0.0006492177,0.000003527917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005970899,"about_ca_system_score_gemma":0.0004279595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001575267,"about_ca_topic_score_gemma":0.00006060122,"domain_scores_codex":[0.9960709,0.0005441129,0.0003756253,0.001085201,0.001019021,0.0009051037],"domain_scores_gemma":[0.999033,0.000328087,0.0001063282,0.0001604102,0.0001344314,0.0002377112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01285732,0.002007652,0.7202973,0.0003123288,0.0000611579,0.004056292,0.004784023,0.00006979905,0.1633696,0.00001236737,0.0003222798,0.09184991],"study_design_scores_gemma":[0.01064473,0.007716677,0.7490485,0.0004401857,0.00008252632,0.0001098008,0.002823622,0.002227287,0.2260969,0.00008125763,0.0003066156,0.0004218863],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945748,0.00006788969,0.0001282646,0.0008808295,0.0007453875,0.002740889,0.0001200915,0.00007743251,0.0006643503],"genre_scores_gemma":[0.9964687,0.000119031,0.0001838014,0.001419853,0.000179534,0.0009262747,0.00003723627,0.00003984615,0.0006257424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09142803,"threshold_uncertainty_score":0.9999341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728895445562982,"score_gpt":0.2794089545519673,"score_spread":0.2621200000963375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}