{"id":"W4283326697","doi":"10.1097/01.hs9.0000843684.97625.7e","title":"S198: BET INHIBITOR PELABRESIB (CPI-0610) COMBINED WITH RUXOLITINIB IN PATIENTS WITH MYELOFIBROSIS — JAK INHIBITOR-NAÏVE OR WITH SUBOPTIMAL RESPONSE TO RUXOLITINIB — PRELIMINARY DATA FROM THE MANIFEST STUDY","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Ruxolitinib; Medicine; Myelofibrosis; Internal medicine; Myeloproliferative neoplasm; Oncology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006503589,0.0008062852,0.001041142,0.0001374477,0.0006338519,0.0001314522,0.000660127,0.00009377904,0.00169183],"category_scores_gemma":[0.0001877456,0.0004491476,0.00006787417,0.001014191,0.0001785776,0.0003120188,0.0009646906,0.0007424924,0.00007737806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004555565,"about_ca_system_score_gemma":0.000768804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009100952,"about_ca_topic_score_gemma":0.002771225,"domain_scores_codex":[0.9941795,0.0008145047,0.0007667155,0.001613223,0.001748251,0.0008777338],"domain_scores_gemma":[0.9954315,0.001222831,0.0003209549,0.002261956,0.0002939061,0.0004687997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2107571,0.008112353,0.7674115,0.00005605328,0.0004784074,0.001580238,0.004011159,0.00008258043,0.00002894579,0.00002379805,0.007080568,0.000377301],"study_design_scores_gemma":[0.03058765,0.06890293,0.8797159,0.0006827813,0.0005612932,0.00009069586,0.01555507,0.0000559539,0.0003623497,0.000004205091,0.002849285,0.0006319398],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98752,0.0001107847,0.000005093715,0.002738694,0.0001148227,0.006965617,0.001979394,0.0001254618,0.0004401639],"genre_scores_gemma":[0.9910964,0.000005159958,0.002334008,0.001007853,0.0002203622,0.002239444,0.001813075,0.0001828154,0.001100823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1801694,"threshold_uncertainty_score":0.999796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02699854354408923,"score_gpt":0.266576492253164,"score_spread":0.2395779487090748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}