{"id":"W4283330060","doi":"10.1007/s00018-022-04406-y","title":"miRNA-486-5p: signaling targets and role in non-malignant disease","year":2022,"lang":"en","type":"review","venue":"Cellular and Molecular Life Sciences","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Ottawa Hospital Foundation","keywords":"Biology; Tensin; PTEN; microRNA; Signal transduction; PI3K/AKT/mTOR pathway; Cancer research; Cell biology; Protein kinase B; Growth factor; Histone acetyltransferase; Transcription factor; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005962581,0.000395456,0.0005762536,0.000217535,0.0002514163,0.00008692572,0.0003682361,0.0001731489,0.00004414533],"category_scores_gemma":[0.0001503105,0.0003571263,0.0002309895,0.0003143848,0.0003318735,0.00001024581,0.000457509,0.0001648926,0.000002955266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002426266,"about_ca_system_score_gemma":0.0004960625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000188523,"about_ca_topic_score_gemma":0.000003120819,"domain_scores_codex":[0.997584,0.0002539714,0.0004285659,0.001008114,0.0003218759,0.000403502],"domain_scores_gemma":[0.9990263,0.00002668097,0.0002135983,0.000347919,0.00002132507,0.0003641697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001251012,0.0006072029,0.0008733275,0.02004395,0.0006032476,0.00112874,0.0003761028,0.0006432222,0.4345477,0.0007723419,0.0008438565,0.5394353],"study_design_scores_gemma":[0.0002964327,0.0001329519,0.00004484739,0.001055982,0.0003338509,0.00002220772,0.0001006718,0.0002338759,0.004250476,0.0001887802,0.9925358,0.0008040929],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01803853,0.980736,0.0002893356,0.00002242548,0.0001173302,0.0005890533,0.0000442092,0.000008763207,0.000154361],"genre_scores_gemma":[0.02573739,0.9732401,0.0002464777,0.000123668,0.00009789725,0.000118109,0.0003385808,0.00004359571,0.00005419895],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9916919,"threshold_uncertainty_score":0.9998881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01568106369130052,"score_gpt":0.2683928451180218,"score_spread":0.2527117814267213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}