{"id":"W4283360296","doi":"10.1002/cncr.34366","title":"Clinical activity of <scp>CC‐90011</scp>, an oral, potent, and reversible <scp>LSD1</scp> inhibitor, in advanced malignancies","year":2022,"lang":"en","type":"article","venue":"Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada; National Institute for Health and Care Research","keywords":"Medicine; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005726959,0.0003557285,0.0005730502,0.0002226031,0.0001671157,0.0003937473,0.0002369048,0.0002383189,0.001475688],"category_scores_gemma":[0.0004066163,0.0001320009,0.0002870817,0.0002590333,0.0003430074,0.0002276273,0.000150542,0.0009939906,0.0003000872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006955814,"about_ca_system_score_gemma":0.0006584508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006635,"about_ca_topic_score_gemma":0.003019484,"domain_scores_codex":[0.9997986,0.00006052724,0.00001816481,0.00002977076,0.00005779363,0.00003517222],"domain_scores_gemma":[0.9996552,0.00005837925,0.00008921293,0.00002289935,0.00003545239,0.000138867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.08510917,0.01146065,0.03901302,0.001641517,0.0008860601,0.0008101775,0.0004263225,0.006123846,0.4548481,0.0004538317,0.009178659,0.3900487],"study_design_scores_gemma":[0.06542098,0.5079957,0.2469674,0.000149712,0.001155979,0.005296892,0.0001924252,0.008091984,0.1400493,0.0004090087,0.02415633,0.0001142705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937115,0.003535117,0.0002515427,0.0001616877,0.00001807349,0.000193877,0.0004015946,0.00005768759,0.001668897],"genre_scores_gemma":[0.9971438,0.001271476,0.0003967975,0.00009094434,0.00002383471,0.00006189728,0.000618597,0.000006676637,0.0003859909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475688,"threshold_uncertainty_score":0.005046844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698781725202081,"score_gpt":0.3216965749094008,"score_spread":0.29470875765738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}