{"id":"W4283360296","doi":"10.1002/cncr.34366","title":"Clinical activity of <scp>CC‐90011</scp>, an oral, potent, and reversible <scp>LSD1</scp> inhibitor, in advanced malignancies","year":2022,"lang":"en","type":"article","venue":"Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada; National Institute for Health and Care Research","keywords":"Medicine; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004931238,0.0001475637,0.0002485404,0.0000627657,0.00009717202,0.00001300079,0.0001520915,0.0001377512,0.000007418183],"category_scores_gemma":[0.0002499432,0.0001598925,0.00007693848,0.0001761181,0.0001086288,0.00001370688,0.0002237174,0.0001889837,7.693028e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003770693,"about_ca_system_score_gemma":0.0001649654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001216852,"about_ca_topic_score_gemma":0.0002100379,"domain_scores_codex":[0.9986387,0.000202492,0.000289943,0.0004448342,0.000168831,0.0002552352],"domain_scores_gemma":[0.9992434,0.00006933165,0.0001924042,0.0003106504,0.00008191654,0.0001022883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003378698,0.0004162577,0.1161634,0.00004797505,0.0000340322,0.000005229764,0.000189114,0.0007559102,0.8589642,0.00003000009,0.001555015,0.02180504],"study_design_scores_gemma":[0.002747037,0.001098332,0.1218015,0.00003062025,0.000034481,0.000002239499,0.0005938023,0.0002010033,0.712177,0.0002930641,0.1609268,0.00009415801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909383,0.007735281,0.0001489471,0.00003561674,0.0003629804,0.0002050248,0.00008713668,0.00000830205,0.0004784346],"genre_scores_gemma":[0.9945053,0.003554965,0.0004772485,0.0001267377,0.0001450302,0.00005930845,0.00005444159,0.00002382025,0.001053116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1593718,"threshold_uncertainty_score":0.6520228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698781725202081,"score_gpt":0.3216965749094008,"score_spread":0.29470875765738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}