{"id":"W4283362162","doi":"10.1002/ehf2.14026","title":"Pharmacogenomic Study of Heart Failure and Candesartan Response from the CHARM Programme","year":2022,"lang":"en","type":"article","venue":"ESC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; Université de Montréal; Hamilton Health Sciences; Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute; British Heart Foundation; AstraZeneca","keywords":"Candesartan; Medicine; Heart failure; Charm (quantum number); Internal medicine; Pharmacogenomics; Cardiology; Pharmacology; Angiotensin II; Particle physics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001043186,0.0002971609,0.0005470188,0.0001345553,0.0004987392,0.00004431112,0.0001633045,0.00005439998,0.001286416],"category_scores_gemma":[0.0000573833,0.000219114,0.0001395623,0.0003909607,0.00009931123,0.00007603753,0.0003210795,0.0004829398,0.00004347087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001461784,"about_ca_system_score_gemma":0.0001882639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00149571,"about_ca_topic_score_gemma":0.000719436,"domain_scores_codex":[0.9973072,0.000640915,0.0004135956,0.0005344103,0.0006120458,0.0004918287],"domain_scores_gemma":[0.9986819,0.0002744169,0.00008752044,0.0006421908,0.00006157192,0.0002524259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003546443,0.002994937,0.3186294,0.00006163363,0.0009704613,0.0002190653,0.009937841,0.00001546915,0.05254452,0.00005274392,0.6092829,0.001744556],"study_design_scores_gemma":[0.005653777,0.002365875,0.04927299,0.000025838,0.0003800278,0.0000834547,0.0165846,0.00003936922,0.0009761049,0.0000145242,0.9243983,0.0002051098],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8619722,0.0003740699,0.000002028695,0.1346776,0.0001230207,0.00267692,0.00005761134,0.00009651575,0.00002003207],"genre_scores_gemma":[0.9945372,0.000006492596,0.001983387,0.001827658,0.000187245,0.0004785518,0.00005624856,0.00004887758,0.0008743671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3151155,"threshold_uncertainty_score":0.9996265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02268362264654815,"score_gpt":0.2822157676063994,"score_spread":0.2595321449598512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}