{"id":"W4283362162","doi":"10.1002/ehf2.14026","title":"Pharmacogenomic Study of Heart Failure and Candesartan Response from the CHARM Programme","year":2022,"lang":"en","type":"article","venue":"ESC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; Université de Montréal; Hamilton Health Sciences; Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute; British Heart Foundation; AstraZeneca","keywords":"Candesartan; Medicine; Heart failure; Charm (quantum number); Internal medicine; Pharmacogenomics; Cardiology; Pharmacology; Angiotensin II; Particle physics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002650241,0.0004704471,0.0006431288,0.0006017212,0.0005633093,0.0005441285,0.0004782364,0.0007256534,0.002124733],"category_scores_gemma":[0.005774013,0.0001769797,0.0007926872,0.001232639,0.0002636802,0.0001770444,0.0005603232,0.0009648564,0.0001871637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003437887,"about_ca_system_score_gemma":0.0006017577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002263687,"about_ca_topic_score_gemma":0.002015434,"domain_scores_codex":[0.9981784,0.001049847,0.00007708749,0.0003339369,0.000211428,0.0001493612],"domain_scores_gemma":[0.9968144,0.001068088,0.0009413068,0.0004773373,0.0002545845,0.0004443896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02465036,0.0007191835,0.9464713,0.0001918756,0.005310313,0.0004174161,0.0001691191,0.001186659,0.005523598,0.00026749,0.002210642,0.01288205],"study_design_scores_gemma":[0.0006268693,0.000676841,0.9962953,0.00001096553,0.0007214168,0.0001671242,0.00002416361,0.0005329918,0.0003554309,0.000135306,0.000440298,0.00001342513],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953985,0.0003553718,0.0003962416,0.0002502779,0.00001497093,0.00004883328,0.003066306,0.0000146149,0.0004549453],"genre_scores_gemma":[0.9956371,0.000102237,0.0005229566,0.0001696233,0.00004542037,0.00009103984,0.003118874,0.000009099334,0.000303548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002650241,"threshold_uncertainty_score":0.01401603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02268362264654815,"score_gpt":0.2822157676063994,"score_spread":0.2595321449598512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}