{"id":"W4283363627","doi":"10.1111/pai.13815","title":"T‐cell‐mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis","year":2022,"lang":"en","type":"letter","venue":"Pediatric Allergy and Immunology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council Canada; Medical Research Council; National Institute for Health and Care Research","keywords":"Medicine; Ivacaftor; Drug allergy; Cystic fibrosis; Family medicine; Library science; Pediatrics; Internal medicine; Drug; Pharmacology; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002780699,0.0004865147,0.00101437,0.001024254,0.0001740098,0.00003281691,0.0001981129,0.0007409301,0.0007789662],"category_scores_gemma":[0.0009810311,0.0004843493,0.00009556668,0.0006395831,0.0002345111,0.00008914887,0.0006513629,0.002699595,0.00008637219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002523297,"about_ca_system_score_gemma":0.0002962753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004146046,"about_ca_topic_score_gemma":0.00001699199,"domain_scores_codex":[0.9967222,0.0003821303,0.0005247763,0.0009695496,0.0004646286,0.0009367815],"domain_scores_gemma":[0.9976208,0.001458231,0.0001593183,0.000476014,0.00009010908,0.0001955829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003593584,0.0003552856,0.009695212,0.001482098,0.0004925495,0.005035342,0.0004018291,0.000009905664,0.004490512,0.00001533578,0.9690596,0.005368775],"study_design_scores_gemma":[0.002123677,0.001805188,0.04152989,0.00004046341,0.000113355,0.0003478559,0.0001345459,0.00003839077,0.00002804015,0.00004349962,0.9532871,0.0005080334],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.7658401,0.06157216,0.0000350867,0.1681831,0.0006287773,0.001709699,0.0004489608,0.0001687391,0.001413345],"genre_scores_gemma":[0.3174379,0.1289194,0.008807827,0.4930169,0.01440675,0.003381648,0.005906004,0.0008701896,0.02725341],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4484022,"threshold_uncertainty_score":0.9997608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00934124885979838,"score_gpt":0.244802898640272,"score_spread":0.2354616497804737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}