{"id":"W4283363627","doi":"10.1111/pai.13815","title":"T‐cell‐mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis","year":2022,"lang":"en","type":"letter","venue":"Pediatric Allergy and Immunology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council Canada; Medical Research Council; National Institute for Health and Care Research","keywords":"Medicine; Ivacaftor; Drug allergy; Cystic fibrosis; Family medicine; Library science; Pediatrics; Internal medicine; Drug; Pharmacology; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001238823,0.000616531,0.0008701618,0.0005719659,0.002532121,0.001454464,0.0009613612,0.02294716,0.003680195],"category_scores_gemma":[0.008905961,0.0004668107,0.0009708289,0.000450424,0.00170481,0.001364716,0.0007317833,0.01300733,0.001522592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003726407,"about_ca_system_score_gemma":0.001981925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006881982,"about_ca_topic_score_gemma":0.00972646,"domain_scores_codex":[0.9988081,0.0003951794,0.0001633199,0.0001086398,0.0002437622,0.0002809437],"domain_scores_gemma":[0.9967973,0.001886937,0.0003035999,0.00009335668,0.0003734492,0.0005453761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"case_report","study_design_scores_codex":[0.0003671327,0.0002236215,0.01542332,0.0001834835,0.00006279282,0.2268113,0.0003861462,0.0002729095,0.001273623,0.004747719,0.7288078,0.02144007],"study_design_scores_gemma":[0.001530586,0.0008700187,0.02762994,0.001645883,0.0003480553,0.290205,0.001618523,0.004751045,0.001817095,0.01417436,0.6553037,0.000105761],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01012588,0.005666023,0.0002111799,0.9527237,0.01559862,0.00002825257,0.00004795879,0.00003450753,0.015564],"genre_scores_gemma":[0.1625534,0.007939689,0.0006100808,0.6819676,0.1297602,0.00007461422,0.00009036159,0.00004226202,0.01696176],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02294716,"threshold_uncertainty_score":0.02703708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00934124885979838,"score_gpt":0.244802898640272,"score_spread":0.2354616497804737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}