{"id":"W4283364422","doi":"10.1158/1538-7445.am2022-ct561","title":"Abstract CT561: KeyVibe-003: Randomized, double-blind, phase 3 study of first-line pembrolizumab with and without vibostolimab (anti-TIGIT) in patients with PD-L1-positive metastatic NSCLC","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Pembrolizumab; Medicine; TIGIT; Internal medicine; Oncology; Atezolizumab; Lung cancer; Phases of clinical research; Gastroenterology; Chemotherapy; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002641704,0.002362268,0.00326594,0.000500271,0.0008607489,0.002022838,0.001436682,0.003014135,0.01004278],"category_scores_gemma":[0.001949065,0.001119997,0.002272,0.0006015828,0.001803701,0.001640459,0.0004664709,0.005525622,0.002576441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001683173,"about_ca_system_score_gemma":0.002607306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001540074,"about_ca_topic_score_gemma":0.004055353,"domain_scores_codex":[0.9992077,0.0004192474,0.00004134045,0.0001457834,0.00006110707,0.0001248897],"domain_scores_gemma":[0.9988919,0.0001963661,0.0002187989,0.00009034792,0.0000900071,0.0005126736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9750609,0.0095575,0.0003826518,0.0004385349,0.0005807295,0.00003191427,0.00004154027,0.0002564679,0.004428043,0.0000949602,0.001527867,0.007598906],"study_design_scores_gemma":[0.9623994,0.03555058,0.0007270239,0.00001812362,0.0001580035,0.00002384587,0.00001008245,0.0002132803,0.0003239432,0.00009063409,0.0004737707,0.00001134005],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593209,0.006894056,0.001819928,0.002244718,0.001605063,0.0168934,0.005291351,0.000559914,0.005370707],"genre_scores_gemma":[0.9632434,0.00296362,0.00317201,0.003385999,0.0007296006,0.01423462,0.003835966,0.0001017985,0.008333039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01004278,"threshold_uncertainty_score":0.03359646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06263140322258151,"score_gpt":0.3967530232811718,"score_spread":0.3341216200585904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}