{"id":"W4283366169","doi":"10.3389/ti.2022.10369","title":"The Cyclophilin-Dependent Calcineurin Inhibitor Voclosporin Inhibits SARS-CoV-2 Replication in Cell Culture","year":2022,"lang":"en","type":"article","venue":"Transplant International","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aurinia (Canada)","funders":"Bontius Stichting; Leids Universitair Medisch Centrum; Universiteit Leiden","keywords":"Calcineurin; Immunosuppression; Medicine; Tacrolimus; Coronavirus disease 2019 (COVID-19); Regimen; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Viral replication; Cyclophilin A; Pharmacology; Virology; Immunology; Transplantation; Virus; Biology; Internal medicine; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003801405,0.0004258371,0.0006844022,0.0002804189,0.0003137065,0.0004314433,0.0003991518,0.0003516335,0.001821747],"category_scores_gemma":[0.000247679,0.00016724,0.0005646652,0.0003445114,0.0001795346,0.0002485349,0.0002515923,0.001020403,0.0008452261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002469134,"about_ca_system_score_gemma":0.0003398143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001641242,"about_ca_topic_score_gemma":0.002856496,"domain_scores_codex":[0.9994336,0.0001248671,0.0001054335,0.00008463125,0.0001662048,0.00008524769],"domain_scores_gemma":[0.9997092,0.00008681266,0.00003607732,0.00007157181,0.00006736212,0.00002893221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003036819,0.0003818984,0.0006031482,0.0001942156,0.00002690784,0.00009718808,0.00008645183,0.0004031709,0.9926018,0.0001537292,0.0007627681,0.004385093],"study_design_scores_gemma":[0.0000329048,0.001178607,0.003808016,0.0000179724,0.0000381324,0.0001715674,0.00005167901,0.002558721,0.9869536,0.00004594393,0.005131579,0.00001136454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687521,0.007062414,0.01053764,0.0004925709,0.0003301699,0.0002169199,0.003071536,0.0002713043,0.00926529],"genre_scores_gemma":[0.9674562,0.005010155,0.01486878,0.0002612545,0.00009976285,0.0002927597,0.005261204,0.00004602633,0.006703916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821747,"threshold_uncertainty_score":0.006094396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0313132315763401,"score_gpt":0.3287053597216777,"score_spread":0.2973921281453376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}