{"id":"W4283366169","doi":"10.3389/ti.2022.10369","title":"The Cyclophilin-Dependent Calcineurin Inhibitor Voclosporin Inhibits SARS-CoV-2 Replication in Cell Culture","year":2022,"lang":"en","type":"article","venue":"Transplant International","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aurinia (Canada)","funders":"Bontius Stichting; Leids Universitair Medisch Centrum; Universiteit Leiden","keywords":"Calcineurin; Immunosuppression; Medicine; Tacrolimus; Coronavirus disease 2019 (COVID-19); Regimen; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Viral replication; Cyclophilin A; Pharmacology; Virology; Immunology; Transplantation; Virus; Biology; Internal medicine; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005638734,0.0001811328,0.0001838092,0.0002044814,0.0002005555,0.00004199193,0.0004616398,0.00007451662,0.00003172022],"category_scores_gemma":[0.00004345437,0.0001413372,0.0001204473,0.0002872924,0.00005619287,0.00008590324,0.00009436521,0.000761169,0.00006722341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003721072,"about_ca_system_score_gemma":0.000157979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002664392,"about_ca_topic_score_gemma":0.0002143046,"domain_scores_codex":[0.9975239,0.00009023792,0.0004551158,0.0005097759,0.00110092,0.0003200275],"domain_scores_gemma":[0.9992267,0.0001031567,0.00009040775,0.0004353571,0.0001168324,0.00002751151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001688017,0.0006351353,0.04324938,0.00005757497,0.00005702675,0.0004376618,0.001471434,0.00001921909,0.9475236,0.00117489,0.002164456,0.001521598],"study_design_scores_gemma":[0.00254858,0.0001975224,0.006280364,0.00004950892,0.0000212845,0.000309794,0.000164297,0.0006349926,0.7552078,0.0002754468,0.2341377,0.0001726836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861105,0.000317371,0.00005370978,0.003091402,0.000537137,0.000577859,0.0001692147,0.00006739403,0.009075408],"genre_scores_gemma":[0.9894409,0.00005943975,0.00002963597,0.009060856,0.0003192476,0.0002499468,0.0001241699,0.00002758642,0.0006882158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2319732,"threshold_uncertainty_score":0.5763565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0313132315763401,"score_gpt":0.3287053597216777,"score_spread":0.2973921281453376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}