{"id":"W4283369873","doi":"10.1111/bjh.18333","title":"Sequential loss of B‐cell target antigens in multiply relapsed high‐grade B‐cell lymphoma treated with targeted therapies","year":2022,"lang":"en","type":"letter","venue":"British Journal of Haematology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada","keywords":"Lymphoma; Medicine; B cell; Antigen; B-cell lymphoma; Oncology; Immunology; Cancer research; Internal medicine; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004510921,0.0002817199,0.000788867,0.0003781976,0.0006738764,0.0007601503,0.0004437376,0.003919529,0.001350979],"category_scores_gemma":[0.002499403,0.0002023653,0.0004078944,0.0004167574,0.0004368661,0.0004385072,0.0003111203,0.002034905,0.0007258927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001461908,"about_ca_system_score_gemma":0.0003942079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001388838,"about_ca_topic_score_gemma":0.002724385,"domain_scores_codex":[0.9996549,0.0001040677,0.00003509734,0.00003908821,0.00007941551,0.0000874923],"domain_scores_gemma":[0.9989311,0.0005150674,0.00009695942,0.00006511509,0.00010446,0.0002873037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.01284579,0.0007249992,0.04219427,0.0004574864,0.000234269,0.6447912,0.0008242439,0.001522974,0.02469764,0.003079277,0.1158912,0.1527367],"study_design_scores_gemma":[0.002384212,0.005844214,0.1414345,0.0002849347,0.0003514202,0.656536,0.0006931978,0.007539902,0.01095551,0.007490814,0.1663697,0.0001155969],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7678403,0.01763687,0.002434736,0.14898,0.007566179,0.0002412896,0.0005006994,0.0002840625,0.05451592],"genre_scores_gemma":[0.9418058,0.003076156,0.0008084953,0.03655338,0.005769196,0.00005690764,0.0002802859,0.00003976994,0.01160995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003919529,"threshold_uncertainty_score":0.01060694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01621198962822781,"score_gpt":0.2593103210133894,"score_spread":0.2430983313851615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}