{"id":"W4283370638","doi":"10.14740/wjon1481","title":"Surrogate Endpoints for Overall Survival in Immune-Oncology Trials of Advanced Gastro-Esophageal Carcinoma","year":2022,"lang":"en","type":"article","venue":"World Journal of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Surrogate endpoint; Clinical endpoint; Internal medicine; Randomized controlled trial; Oncology; Response Evaluation Criteria in Solid Tumors; Progression-free survival; Clinical trial; Carcinoma; Overall survival; Phases of clinical research","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.006968749,0.0001686833,0.00184924,0.0006888183,0.00007177684,0.000003739444,0.0002433126,0.00008212961,0.001062145],"category_scores_gemma":[0.0004162949,0.0001477812,0.0006551524,0.0003478761,0.0001300645,0.00007442479,0.00007805636,0.0005644582,7.312431e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001236164,"about_ca_system_score_gemma":0.001449555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007527483,"about_ca_topic_score_gemma":0.0002492595,"domain_scores_codex":[0.9958879,0.001060318,0.002184383,0.0001800244,0.0003174877,0.0003698312],"domain_scores_gemma":[0.9960569,0.001501743,0.001958773,0.0001831625,0.0001981257,0.00010131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.2699752,0.002700123,0.04196788,0.0001816505,0.001060245,0.001845969,0.001984083,0.0004969595,0.4220458,0.0005740353,0.004739892,0.2524281],"study_design_scores_gemma":[0.1209319,0.03864397,0.1803792,0.0001451787,0.0004872672,0.002483299,0.002530502,0.0000665761,0.01553819,0.0006478268,0.6378455,0.0003006353],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862309,0.004473458,0.00005969495,0.003841952,0.002910917,0.0007070093,0.00006246779,0.000006307632,0.001707315],"genre_scores_gemma":[0.995621,0.0002406349,0.002190311,0.000536651,0.0003217502,0.0000490902,0.00001550409,0.00002501271,0.0009999915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6331056,"threshold_uncertainty_score":0.999851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04804802462430779,"score_gpt":0.3664403915138034,"score_spread":0.3183923668894956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}