{"id":"W4283370847","doi":"10.1097/01.hs9.0000848944.56958.95","title":"P1522: LONG-TERM EFFICACY AND SAFETY OF THE ORAL PYRUVATE KINASE ACTIVATOR MITAPIVAT IN ADULTS WITH NON–TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Hemolysis; Ineffective erythropoiesis; Thalassemia; Adverse effect; Pyruvate kinase; Internal medicine; Erythropoiesis; Anemia; Pharmacology; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001790996,0.0002531889,0.0004554727,0.0000505044,0.0002114135,0.000009539442,0.000172029,0.0001268528,0.001258144],"category_scores_gemma":[0.00003453166,0.0001452734,0.00009309514,0.0005047064,0.000146215,0.00006911273,0.0001721918,0.0006401167,0.000003788889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001156406,"about_ca_system_score_gemma":0.0002364541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002513287,"about_ca_topic_score_gemma":0.0005812866,"domain_scores_codex":[0.9982653,0.00009407201,0.0003920061,0.0004007358,0.0004987514,0.0003491966],"domain_scores_gemma":[0.9991328,0.00009115274,0.0001325394,0.000445111,0.00005009881,0.0001483579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02644065,0.002521735,0.9008892,0.00176522,0.0004619621,0.001682837,0.00621174,0.0004092758,0.02449524,0.00009224543,0.001103884,0.03392604],"study_design_scores_gemma":[0.03341475,0.002180486,0.9337189,0.002553761,0.0003777946,0.0004513846,0.00666147,0.0001851709,0.0183056,0.00001266344,0.001583164,0.0005548371],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955242,0.0006886104,0.00001424861,0.001296285,0.0001334017,0.001229234,0.0000285899,0.00003177177,0.001053602],"genre_scores_gemma":[0.99784,0.0004724938,0.00008924359,0.0002360218,0.00002305846,0.0000526818,0.00001997213,0.0000465206,0.001219964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0333712,"threshold_uncertainty_score":0.9996548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00765436916007379,"score_gpt":0.2325502291694925,"score_spread":0.2248958600094187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}