{"id":"W4283370847","doi":"10.1097/01.hs9.0000848944.56958.95","title":"P1522: LONG-TERM EFFICACY AND SAFETY OF THE ORAL PYRUVATE KINASE ACTIVATOR MITAPIVAT IN ADULTS WITH NON–TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Hemolysis; Ineffective erythropoiesis; Thalassemia; Adverse effect; Pyruvate kinase; Internal medicine; Erythropoiesis; Anemia; Pharmacology; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006855949,0.0005602068,0.001098688,0.0001652261,0.0002573926,0.0007608805,0.0003713608,0.0007832454,0.003525813],"category_scores_gemma":[0.0007839223,0.0002037216,0.0008217444,0.0002306998,0.0003155849,0.0006059738,0.0002824299,0.001677457,0.0007778417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004421449,"about_ca_system_score_gemma":0.0006114391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000463122,"about_ca_topic_score_gemma":0.0007975549,"domain_scores_codex":[0.9998032,0.00007118765,0.00002091365,0.00004135898,0.00002513963,0.00003823409],"domain_scores_gemma":[0.9996086,0.00006119761,0.0001078336,0.00002542913,0.00003766351,0.0001593285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6335294,0.02670367,0.01566638,0.001823165,0.002189329,0.0005335884,0.0002377899,0.001251728,0.02478798,0.0001677059,0.006353011,0.2867563],"study_design_scores_gemma":[0.2966907,0.6273674,0.06103037,0.0002367736,0.00161303,0.0009232503,0.000137208,0.001419719,0.004457542,0.0001920612,0.005888964,0.00004303332],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905088,0.005904138,0.0002464436,0.0003535532,0.0001118971,0.0004996141,0.000919233,0.00006230519,0.001394042],"genre_scores_gemma":[0.9936329,0.002191346,0.0003312703,0.0006870073,0.0001523322,0.0005681309,0.001232566,0.00001031261,0.001194078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003525813,"threshold_uncertainty_score":0.01179504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00765436916007379,"score_gpt":0.2325502291694925,"score_spread":0.2248958600094187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}