{"id":"W4283372513","doi":"10.1097/01.hs9.0000846600.20422.ca","title":"P933: DARATUMUMAB (D) IN COMBINATION WITH VD OR D-RD IN RELAPSED OR REFRACTORY MULTIPLE MYELOMA: SUBGROUP ANALYSIS OF CASTOR AND POLLUX STUDIES IN PATIENTS WITH EARLY OR LATE RELAPSE AFTER INITIAL THERAPY","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Lenalidomide; Daratumumab; Clinical endpoint; Oncology; Dexamethasone; Subgroup analysis; Clinical trial; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003574012,0.0009247493,0.002994245,0.0005552812,0.0003024507,0.00105203,0.0007646082,0.0007830305,0.001439078],"category_scores_gemma":[0.002548172,0.0003620271,0.006685529,0.0006654394,0.0004961591,0.0005292948,0.0006295387,0.001194826,0.0001588324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006781417,"about_ca_system_score_gemma":0.000952272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001041763,"about_ca_topic_score_gemma":0.002734557,"domain_scores_codex":[0.9980395,0.001134976,0.0001956304,0.0002721945,0.00018134,0.0001763839],"domain_scores_gemma":[0.9985084,0.0005418001,0.0003697538,0.0001989653,0.00008551419,0.0002955922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8361003,0.001698722,0.07488533,0.001285403,0.04267177,0.0002127457,0.0002006079,0.001071454,0.006823065,0.0001703053,0.001067999,0.03381222],"study_design_scores_gemma":[0.2930944,0.179254,0.4191379,0.0004310191,0.08997667,0.001127322,0.0006320044,0.00467287,0.004172515,0.001043763,0.006233455,0.0002240752],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925103,0.006128622,0.00019102,0.0001324455,0.00007238521,0.0002093052,0.0003943154,0.00001059827,0.000350934],"genre_scores_gemma":[0.9978675,0.0008004768,0.000205322,0.0001875847,0.00009114071,0.0001378709,0.0005040226,0.00000510542,0.0002010255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003574012,"threshold_uncertainty_score":0.01890141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03893365579631453,"score_gpt":0.3151773999234155,"score_spread":0.276243744127101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}