{"id":"W4283375792","doi":"10.1016/j.bbagrm.2022.194840","title":"Chemical biology and pharmacology of histone lysine methylation inhibitors","year":2022,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Genentech; Innovative Medicines Initiative; Kungliga Tekniska Högskolan; Ontario Genomics Institute; Janssen Pharmaceuticals; Merck KGaA; McGill University; Takeda Canada; Genome Canada; Boehringer Ingelheim; Pfizer; Bristol-Myers Squibb","keywords":"Epigenetics; EZH2; Histone; Methyltransferase; Methylation; Chemical biology; Biology; Cancer research; Histone methylation; Computational biology; Pharmacology; DNA methylation; Biochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000732174,0.001503702,0.001697192,0.001906314,0.0002886326,0.001127342,0.001260702,0.001185803,0.00226086],"category_scores_gemma":[0.0006725559,0.0005936476,0.0005574201,0.001880922,0.0007778328,0.001322113,0.0007830716,0.002773996,0.002419143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001047194,"about_ca_system_score_gemma":0.000851536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094338,"about_ca_topic_score_gemma":0.001986049,"domain_scores_codex":[0.9997968,0.00002876935,0.00002351948,0.00003536663,0.00008574727,0.00002993043],"domain_scores_gemma":[0.9998216,0.00007562783,0.00003102674,0.00000945415,0.00004220513,0.00002019559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002763918,0.000237305,0.0001538877,0.01383166,0.0001303587,0.0003336428,0.00005936303,0.001464304,0.009397049,0.01272566,0.05616639,0.905224],"study_design_scores_gemma":[0.00004675927,0.0001183075,0.000394419,0.001005267,0.00008100268,0.0006999517,0.00001564564,0.0001690542,0.002399166,0.002058678,0.9929904,0.00002141969],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001298648,0.9981903,0.0002466084,0.0001432301,0.0002136521,0.000005898222,0.00002156258,0.000009009631,0.001039853],"genre_scores_gemma":[0.0008614114,0.9973854,0.0002363346,0.0001912874,0.0001774956,0.00001137835,0.00004152838,0.000002072294,0.001093084],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00226086,"threshold_uncertainty_score":0.007597983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02477940912485791,"score_gpt":0.3370813015423985,"score_spread":0.3123018924175406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}