{"id":"W4283377101","doi":"10.1017/cjn.2022.85","title":"GP.1 The genetic basis of multiple sclerosis severity","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Multiple sclerosis; Heritability; Genome-wide association study; Genetic architecture; Genetic variation; SNP; Single-nucleotide polymorphism; Genetic association; Biology; Genetic predisposition; Genetic heterogeneity; Population; Cohort; Locus (genetics); Medicine; Genetics; Oncology; Gene; Internal medicine; Quantitative trait locus; Immunology; Genotype; Phenotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002517169,0.000404319,0.0002320308,0.0006291725,0.0002368675,0.0004740958,0.0002939446,0.0003925708,0.01035225],"category_scores_gemma":[0.001405817,0.000111308,0.0001956913,0.0009038631,0.0002745245,0.0001770329,0.0003240909,0.0004210307,0.0009455069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003101131,"about_ca_system_score_gemma":0.0003654548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008618547,"about_ca_topic_score_gemma":0.003788343,"domain_scores_codex":[0.9998496,0.00003144111,0.000007628839,0.00005122612,0.00004055908,0.00001955976],"domain_scores_gemma":[0.9996403,0.0001141974,0.0001142668,0.00002630361,0.00005629822,0.0000485622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001200636,0.0001022917,0.8506059,0.0003402163,0.0004246281,0.001736221,0.0004538639,0.001197174,0.03204352,0.0029576,0.008119769,0.1008181],"study_design_scores_gemma":[0.00004096348,0.0001174744,0.9918522,0.00005156832,0.0001369834,0.001295358,0.00007441619,0.0009541523,0.0007902822,0.001951933,0.002726288,0.000008373235],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816115,0.001954491,0.001956089,0.001207317,0.00005824914,0.00005464574,0.005473464,0.0001784711,0.007505736],"genre_scores_gemma":[0.9953423,0.0005056837,0.0009316109,0.00008600514,0.00004447286,0.00001983298,0.001105819,0.0000260072,0.001938309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01035225,"threshold_uncertainty_score":0.03463173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08848744409339299,"score_gpt":0.2982605477515818,"score_spread":0.2097731036581889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}