{"id":"W4283381482","doi":"10.14740/wjon1478","title":"Promoter Gene Methylation Regulates Clooxygenase-2 Expression in Androgen-Dependent and Independent Prostate Cancer Cells","year":2022,"lang":"en","type":"article","venue":"World Journal of Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chang Gung Medical Foundation","keywords":"DU145; LNCaP; DNA methylation; Cancer research; Prostate cancer; Methylation; Bisulfite sequencing; Molecular biology; Medicine; Biology; Cancer; Gene expression; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040485,0.0001654723,0.0001561323,0.0001919777,0.0001324175,0.0001829312,0.0001265961,0.0001265474,0.001714998],"category_scores_gemma":[0.0001328263,0.000107512,0.000235335,0.0001815669,0.0001112993,0.0001046352,0.0001206391,0.0003371869,0.0003035004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407216,"about_ca_system_score_gemma":0.0002897796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002023114,"about_ca_topic_score_gemma":0.003070626,"domain_scores_codex":[0.9998901,0.00001204669,0.000005401658,0.00002826846,0.00004087682,0.00002330984],"domain_scores_gemma":[0.9999341,0.000009849633,0.00001869679,0.000005777046,0.00001833544,0.00001319849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001432474,0.00002523305,0.001536939,0.00005073568,0.000008430758,0.00004277979,0.00004043296,0.0000648957,0.9955379,0.00007340984,0.0001029873,0.002373114],"study_design_scores_gemma":[0.0000249392,0.0004303365,0.04011762,0.00001298386,0.00005145207,0.0003641159,0.00008921121,0.001563511,0.9507523,0.00008103522,0.006502204,0.00001024707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875107,0.005552782,0.003841483,0.0001529075,0.00005715763,0.00003400769,0.0008064381,0.0001494795,0.001894992],"genre_scores_gemma":[0.9923354,0.001722374,0.001573549,0.00005587925,0.00001517157,0.00004374287,0.0008705646,0.00001240209,0.003370919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002023114,"threshold_uncertainty_score":0.005737245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173785058769065,"score_gpt":0.2814870737005732,"score_spread":0.2697492231128825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}